海姆泊芬光动力疗法治疗鲜红斑痣专家共识(2024)

Expert consensus on hematoporphyrin monomethyl ether-mediated photodynamic therapy for treating port-wine stains(2024)

鲜红斑痣是一种以皮肤表面毛细血管和毛细血管后微静脉结构异常为特征的先天性、进行性毛细血管畸形。好发于面颈部,明显的外貌特征可能会带来社会歧视,严重影响患者的情绪和身心健康。光动力疗法作为鲜红斑痣的一种新兴疗法,展现了良好的安全性和有效性,是治疗鲜红斑痣最有前景的策略之一。自2017年以来,海姆泊芬光动力疗法已被广泛用于鲜红斑痣患者,为进一步规范海姆泊芬光动力疗法的临床应用,共识组专家结合国内外最新研究进展,在广泛讨论基础上制订本共识,为临床医生提供指导意见。

Port-wine stain(PWS)is a congenital and progressive capillary malformation characterized by structural abnormalities of intradermal capillaries and postcapillary venules.The visible skin manifestations on the face and neck are often considered a disfigurement,and the accompanying social stigma often causes serious emotional and physical impact.As a new treatment for PWS,photodynamic therapy(PDT)mediated by hemoporfin,also known as hematoporphyrin monomethyl ether(HMME),has shown good safety and efficacy,and is one of the most promising strategies for the treatment of PWS.Since 2017,HMME-PDT has been widely used for the treatment of PWS.To further standardize the clinical application of HMME-PDT,experts in the consensus group developed this consensus based on the latest research achievements and extensive discussions,so as to provide guidance for clinicians.