中医药调控线粒体损伤干预呼吸系统疾病的研究进展

Research Progress on Chinese Medicine Regulation of Mitochondrial Damage for Intervention in Respiratory System Diseases

线粒体是细胞中产生能量的重要细胞器,各种原因导致的线粒体损伤是促进疾病进展的重要因素。线粒体损伤涉及结构损伤及线粒体 DNA 损伤,与呼吸系统疾病发生发展密切相关。近年来,大量研究证实线粒体损伤在呼吸系统疾病进展中扮演重要角色,可能是中医药治疗呼吸系统疾病的重要靶点。本文综述了中医药调控线粒体损伤在干预慢性阻塞性肺疾病、肺癌、肺纤维化、急性肺损伤、哮喘、肺炎等呼吸系统疾病中的作用,旨在为呼吸系统疾病的发病机制及药物作用靶点研究提供依据。

Mitochondria are important organelles in cells for energy production,and mitochon-drial damage caused by various reasons is an important factor promoting disease progression.Mitochondrial damage involves structural damage and mitochondrial DNA damage,which are closely related to the occurrence and development of respiratory system diseases.In recent years,a large number of studies have confirmed the significant role of mitochondrial damage in the progression of respiratory system diseases,which may be an important target for the treatment of respiratory system diseases with traditional Chinese medicine(TCM).This article reviews the role of TCM in regulating mitochondrial damage for intervention in respiratory system diseases such as chronic obstructive pulmonary disease,lung cancer,pulmonary fibrosis,acute lung injury,asthma,and pneumonia,aiming to provide a basis for the study of the pathogenesis and drug action targets of respiratory system diseases.