中医药调控线粒体氧化应激治疗肺部炎症性疾病研究进展

Treatment of Pulmonary Inflammatory Diseases by Traditional Chinese Medicine Through Regulating Mitochondrial Oxidative Stress:A Review

肺纤维化、慢性阻塞性肺疾病、急性肺损伤、哮喘和感染性肺炎等疾病是全球常见的肺部炎症性疾病。有证据表明,线粒体在受到炎症刺激时会产生大量的活性氧,形成氧化应激,影响肺部炎症性疾病的发生和发展。随着研究的深入,中医药在治疗肺部炎症性疾病方面取得了显著进展。越来越多的证据表明,中药单体及其活性成分,以及中药复方能够通过多靶点、多通路机制改善线粒体氧化应激状态,从而有效治疗肺部炎症性疾病。目前,国内外尚未对中医药在该领域的研究进行系统性回顾和总结。因此,该文旨在归纳和总结中医药通过调控线粒体氧化应激干预肺部炎症性疾病的作用机制,为其临床应用提供科学依据,并为中医药防治肺部炎症性疾病的深入研究提供新的思路和参考。

Pulmonary fibrosis,chronic obstructive pulmonary disease,acute lung injury,asthma,and infectious pneumonia are common pulmonary inflammatory diseases worldwide.There is evidence that mitochondria produce a large amount of reactive oxygen species(ROS)when stimulated by inflammation,leading to oxidative stress that affects the onset and progression of pulmonary inflammatory diseases.With indepth research,traditional Chinese medicine(TCM)has made significant progress in the treatment of pulmonary inflammatory diseases.An increasing amount of evidence indicates that single TCM and their active components,as well as TCM compound formulas,can improve mitochondrial oxidative stress status through multi-target and multi-pathway mechanisms,thereby effectively treating pulmonary inflammatory diseases.Currently,there is a lack of systematic review and summary of TCM research in this field both domestically and internationally.Therefore,this article aims to summarize and conclude the mechanisms by which TCM regulates mitochondrial oxidative stress to intervene in pulmonary inflammatory diseases,providing a scientific basis for its clinical application and offering new ideas and references for in-depth research on the prevention and treatment of pulmonary inflammatory diseases with TCM.