NLR、LMR、PLR及CAR预测广泛期小细胞肺癌患者预后的价值

Prognostic value of NLR,LMR,PLR,and CAR in patients with extensive‑stage small cell lung cancer

目的:探讨中性粒细胞-淋巴细胞比值(NLR)、淋巴细胞-单核细胞比值(LMR)、血小板-淋巴细胞比值(PLR)及C反应蛋白-白蛋白比值(CAR)预测小细胞肺癌患者预后的价值。方法:选取2020年10月至2022年6月在武汉科技大学附属孝感市中心医院诊治的46例局限期小细胞肺癌患者作为局限期组,52例转移小细胞肺癌患者作为广泛期组进行了回顾性分析。对纳入的98例患者中根据是否出现死亡患者,分为死亡组和生存组。收集并分析临床资料、血常规检查。结果:广泛期组NLR、LMR、PLR及CAR值高于局限期组的水平(P<0.05),生存组NLR、LMR、PLR及CAR值低于死亡组(P<0.05);生存组和死亡组在TNM分期、淋巴结转移、远处转移等方面比较差异有统计学意义(P<0.05)。结论:广泛期肺癌患者血清NLR、LMR、PLR及CAR水平高于局限期组,可为临床工作中预测小细胞肺癌预后提供参考。

Objective:To investigate the prognostic value of neutrophil⁃lymphocyte ratio(NLR),lymphocyte⁃monocyte ratio(LMR),platelet⁃lymphocyte ratio(PLR),and C⁃reactive protein⁃albumin ratio(CAR)in patients with small cell lung cancer.Methods:A total of 46 patients with non⁃metastatic small⁃cell lung cancer treated in Xiaogan Central Hospital Affiliated to Wuhan Univer⁃sity of Science and Technology from October 2020 to June 2022 were selected for retrospective analy⁃sis as the limited⁃stage group,and 52 patients with metastatic small⁃cell lung cancer were included as the extensive⁃stage group.All the 98 patients were also categorized into death group and survival group according to their outcome.Clinical data and routine blood tests were collected and analyzed.Results:The values of NLR,LMR,PLR,and CAR in the lung cancer group were higher than those in the control group(P<0.05),while the values of NLR,LMR,PLR,and CAR in death group were lower than those in death group(P<0.05).There were significant differences in the TNM stage,lymph node metastasis and distant metastasis between the death group and survival group(P<0.05).Conclusion:The serum levels of NLR,LMR,PLR,and CAR in patients with distant met⁃astatic lung cancer were higher than those in the control group,which can provide reference for predict⁃ing the prognosis of small cell lung cancer in clinical work.