TBI后应激性肠屏障损害的研究进展

Research progress on stress induced intestinal barrier damage after TBI

创伤性脑损伤后应激性肠屏障损害增加了患者的死亡风险,严重影响疾病预后,目前其发病机制和治疗策略仍不完全清楚。本文旨在总结创伤性脑损伤应激性肠屏障损害的病理机制和保护策略等关键问题的研究进展,发现肠上皮细胞通透性增加、紧密连接、内质网应激、细胞自噬、缺血再灌注损伤可能是创伤性脑损伤应激后肠屏障损害的主要机制。此外,本文还综述了迷走神经刺激、益生菌、外源性补充饥饿素、氧疗等对创伤性脑损伤后应激性肠屏障损害的保护作用。本文将为探索精准有效的创伤性脑损伤后应激性肠屏障损害防治提供新视角和干预靶点。

Stress induced intestinal barrier damage after traumatic brain injury significantly increases the risk of mortality in pa-tients and seriously affects disease prognosis.However,the pathogenesis and treatment strategies are still not fully understood.This article aims to summarize the research progress on key issues such as the pathological mechanism and protective strategies of stress induced intestinal barrier damage in traumatic brain injury,it points out that increased permeability of intestinal epithelial cells,tight junctions,endoplasmic reticulum stress,autophagy,and ischemia-reperfusion injury may be the main mechanisms of intestinal barrier damage after traumatic brain injury.This article reviews the protective effects of vagus nerve stimulation,probiot-ics,exogenous supplementation of hunger hormone,and oxygen therapy on stress induced intestinal barrier damage after traumatic brain injury.This article will provide a new perspective and intervention targets for exploring precise and effective prevention and treatment of stress induced intestinal barrier damage after traumatic brain injury.