血清转化生长因子-β、白细胞介素-23在婴幼儿呼吸道合胞病毒肺炎患儿中的表达及其与病情严重程度的相关性

The expression of serum TGF-βand IL-23 in infants with respiratory syncytial virus pneumonia and their correlation with the severity of the disease

目的观察婴幼儿呼吸道合胞病毒(respiratory syncytial virus,RSV)肺炎患儿的血清转化生长因子-β(transforming growth factor-β,TGF-β)和白细胞介素-23(interleukin 23,IL-23)表达水平,并分析TGF-β、IL-23与患儿病情严重程度的相关性。方法采集2021年1月至2023年12月郴州市第一人民医院收治的100例婴幼儿RSV肺炎患儿资料,纳入观察组,另采集同期医院健康体检的100例婴幼儿资料,纳入对照组。患儿及健康婴幼儿的疾病资料、体检资料等均保存完整。观察组患儿入院后根据病情严重程度分为轻度组(37例)、重度组(63例),比较对照组与不同病情严重程度患儿的基线资料及TGF-β、IL-23水平,重点分析血清TGF-β、IL-23与婴幼儿呼吸道合胞病毒肺炎病情严重程度的相关性。结果相较于对照组,轻度组、重度组的TGF-β较低、IL-23水平较高;相较于轻度组,重度组的TGF-β较低、IL-23水平较高。经Logistic回归分析,婴幼儿RSV肺炎患儿病情严重程度可能与患儿TGF-β、IL-23有关(P<0.05)。受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)结果显示,患儿入院时的TGF-β、IL-23评估重度病情有较好效能,AUC均大于0.70,有评估价值,且二者联合评估AUC为0.937,评估价值更佳(P<0.05)。结论婴幼儿RSV肺炎患儿的血清TGF-β普遍呈低表达、IL-23呈高表达,且二者与患儿的病情严重程度有关,病情越严重的患儿的TGF-β越低、IL-23越高,联合测定婴幼儿RSV肺炎患儿TGF-β、IL-23水平或可早期评估患儿病情严重程度。

Objective To observe the expression of serum transforming growth factor-β(Transforming growth factor-β,TGF-β)and interleukin 23(Interleukin 23,IL-23)in infants with respiratory syncytial virus(RSV)pneumonia,and to analyze the possible relationship between TGF-β,IL-23 and the severity of the disease.Method The data of 100 infants with RSV pneumonia admitted to Chenzhou First People's Hospital from January 2021 to December 2023 were collected and included in the observation group.The data of 100 infants who underwent physical examination in the hospital during the same period were collected and included in the control group.The disease data and physical examination data of children and healthy infants were preserved intact.The observation group were divided into mild group(n=37)and severe group(n=63)according to the severity of the disease after admission.The levels of TGF-βand IL-23 in the control group and children with different severity of disease,the baseline data of children with different severity of disease,and the levels of TGF-βand IL-23 were compared.The correlation between serum TGF-βand IL-23 and the severity of respiratory syncytial virus pneumonia in infants was analyzed.Result Compared with the control group,the mild group and the severe group had lower TGF-βand higher IL-23;compared with the mild group,the TGF-βin the severe group was lower and the IL-23 was higher(P<0.05).Through Logistic regression analysis,the severity of RSV pneumonia in infants and young children may be related to TGF-β,and IL-23 levels(P<0.05).The ROC curve results showed that TGF-βand IL-23 at the time of admission had a certain efficacy in assessing severe illness,with AUC greater than 0.70 and evaluation value.Moreover,the combined evaluation AUC of the two was 0.937,indicating better evaluation value(P<0.05).Conclusion The serum levels of TGF-βand IL-23 in infants with RSV pneumonia are generally low and high,and the two are related to the severity of the disease.The more severe the disease,the lower the TGF-βand the higher the IL-23.The combined determination of TGF-βand IL-23 levels in infants with RSV pneumonia may be used to evaluate the severity of the disease in early stage.