高级别浆液性卵巢癌患者血清CD26、CD109与临床病理特征和预后的关系研究

Study on the relationship between serum CD26,CD109 and clinicopathological features and prognosis in patients with high-grade serous ovarian cancer

目的 探讨高级别浆液性卵巢癌(HGSOC)患者血清分化簇26(CD26)、分化簇109(CD109)与临床病理特征和预后的关系。方法 选取2019年7月至2020年7月宿迁市第一人民医院及泰兴市人民医院收治的145例HGSOC患者作为HGSOC组,选取同期在我院体检的100例正常健康者作为对照组。采用酶联免疫吸附法测定两组的血清CD26、CD109水平并进行比较,分析CD26、CD109水平与HGSOC患者临床病理特征的关系,采用Cox回归模型分析HGSOC患者预后的影响因素。绘制Kaplan-Meier生存曲线分析血清CD26、CD109高水平和低水平患者的3年总生存率情况。结果 与对照组比较,HGSOC组血清CD26、CD109水平显著升高(P<0.05)。年龄、肿瘤直径、腹水与否、术前CA125水平不同的患者血清CD26、CD109水平比较差异无统计学意义(P>0.05),淋巴结转移、FIGO分期Ⅲ+Ⅳ期HGSOC患者血清CD26、CD109水平显著高于无淋巴结转移、FIGO分期Ⅰ+Ⅱ期HGSOC患者(P<0.05)。Kaplan-Meier生存曲线显示,CD26高水平组3年总生存率[59.72%(43/72)]显著低于CD26低水平组[79.10%(53/67)](P<0.05);CD109高水平组3年总生存率[62.50%(50/80)]显著低于CD109低水平组[77.97%(46/59)](P<0.05)。Cox回归模型分析显示,淋巴结转移、FIGO分期Ⅲ+Ⅳ期、血清CD26高水平、血清CD109高水平是HGSOC预后不良的危险因素(P<0.05)。结论 血清CD26、CD109在HGSOC患者中呈高表达,其表达水平升高与远处转移、FIGO分期Ⅲ+Ⅳ期及预后不良有关。

Objective:To investigate the relationship between serum cluster differentiation 26(CD26),serum cluster differentiation 109(CD109)and clinicopathological features and prognosis in patients with high-grade serous ovarian cancer(HGSOC).Methods:A total of 145 HGSOC patients admitted to Suqian First Hopital and Taixing People’s Hospital from July 2019 to July 2020 were selected as the HGSOC group,and 100 normal healthy women who underwent physical examinations in the same hospital during the same period were selected as the control group.Enzyme linked immunosorbent assay was used to measure the serum levels of CD26 and CD109 in two groups and compare them.The relationship between CD26 and CD109 levels and clinical pathological characteristics of HGSOC patients was analyzed,and Cox regression model was used to analyze the factors of the prognosis of HGSOC patients.Kaplan-Meier survival curves were drawn to analyze the 3-year overall survival rate of patients with high and low levels of serum CD26 and CD109.Results:Compared with the control group,the levels of serum CD26 and CD109 in HGSOC group were significantly increased(P<0.05).There were no significant differences in serum CD26 and CD109 levels among patients with different ages and tumor diameters,with or without ascites and preoperative CA125 levels(P>0.05).The levels of serum CD26 and CD109 in patients with lymph node metastasis and FIGO stageⅢ+ⅣHGSOC were significantly higher than those in patients without lymph node metastasis and FIGO stageⅠ+ⅡHGSOC(P<0.05).The Kaplan-Meier survival curve showed that the 3-year overall survival rate in CD26 high-level group[59.72%(43/72)]was significantly lower than that in CD26 low-level group[79.10%(53/67),P<0.05].The 3-year overall survival rate in CD109 high-level group[62.50%(50/80)]was significantly lower than that in CD109 low-level group[77.97%(46/59),P<0.05].Cox regression model analysis showed that lymph node metastasis,FIGO stageⅢ+Ⅳ,high serum CD26 level and high serum CD109 level were risk factors for poor prognosis of HGSOC(P<0.05).Conclusions:Serum CD26 and CD109 are highly expressed in HGSOC patients,and their elevated expression levels are related to distant metastasis,FIGO stageⅢ+Ⅳand poor prognosis.