基于Neo4j图数据库的我国运动干预阿尔茨海默病研究知识图谱可视化分析

Knowledge graph visualization of Chinese studies on exercise interventions for Alzheimer's disease based on the Neo4j graph database

目的对国内运动干预阿尔茨海默病(AD)相关研究文献进行梳理呈现,系统分析该领域理论进展和研究现状。方法以中国知网数据库中运动干预AD的核心期刊论文为研究对象,采用内容分析法对研究主题、方法、结论梳理分析,基于Neo4j图数据库完成存储和可视化,呈现国内运动干预AD研究的全貌。结果国内运动干预AD的研究中理论综述较多,占60%;实验研究约占24%。实验研究均得出运动干预AD的有效性,各研究中不同运动形式、联合疗法均被证明有效,缺乏对不同时间频次、强度运动的对照研究。文献综述多为对生物机制和疗效的理论综述,系统综述较少,仅8篇meta分析和1篇知识图谱可视化分析,缺乏对不同时间、形式、强度运动疗效的系统性比较综述。结论运动可通过多种机制来延缓AD病理变化,其剂量效应也已有体现,但对于不同人群、运动方案的调节作用研究还不透彻,对额外变量的控制还不够严格,降低了研究的可信度和可比性,且缺乏不同运动方案对AD疗效的系统性综述。

s:Objective To organize and present the domestic research literature on exercise interventions for Al-zheimer's Disease(AD),and to systematically analyze the theoretical progress and current state of research in this field.Methods The core journal articles on exercise interventions for AD in CNKI database were taken as the research ob-jects.Content analysis was used to sort out and analyze the research themes,methods,and conclusions,and the results were stored and visualized using the Neo4j graph database.Results Theoretical reviews on exercise interventions for AD in China accounted for 60%,while experimental studies accounted for about 24%.All experimental studies had concluded the effectiveness of exercise interventions for AD,with different forms of exercise and combined therapies proven to be ef-fective in various studies.But there was a lack of comparative studies on different frequencies and intensities of exercise.Most literature reviews were theoretical reviews of biological mechanisms and efficacy,with fewer systematic reviews,in-cluding only 8 meta-analyses and 1 knowledge map visualization analysis,lacking systematic comparative reviews on the ef-ficacy of different forms,intensities,and times of exercise.Conclusions Exercise can delay the pathological changes of AD through various mechanisms,and its dosage effects have been demonstrated.However,research on the regulatory ef-fects of different populations and exercise programs is not yet thorough,and the control of extraneous variables is not strict enough,which reduces the credibility and comparability of the studies.Additionally,there is a lack of systematic reviews on the efficacy of different exercise programs for treating AD.