弓形虫入侵过程中主要分泌蛋白的研究进展

Research progress of major secreted proteins during Toxoplasma gondii invasion

弓形虫是顶复门的一种专性细胞内寄生虫。该寄生虫寄生于宿主体内时,利用一系列分泌蛋白完成其入侵过程。弓形虫入侵宿主过程的关键蛋白包括:前端的微线体蛋白(MICs),参与形成顶端复合体;棒状体蛋白(ROPs),协助建立细胞内环境;致密颗粒蛋白(GRAs),调节入侵过程中多个步骤。文章综述了弓形虫入侵过程中主要的分泌蛋白,并对弓形虫疫苗的未来发展进行了前瞻性思考,以期为探索弓形虫的致病原理及为疫苗开发提供参考。

Toxoplasma gondii is an obligate intracellular parasite of the parietal phylum.The parasite uses a series of secreted proteins to complete its invasion of the host.Key proteins involved in Toxoplasmagondii's host invasion process include:Microfilament proteins(MICs)at the front end,which participate in the formation of apical complex;Rod body proteins(ROPs),which help to establish intracellular environment;Dense particle proteins(GRAs),which regulate multiple steps in the invasion process.In the paper,the main secreted proteins during the invasion of Toxoplasma gondii were summarized,and the future development of Toxoplasmagondiivaccine was prospectively considered,in order to provide a reference for exploring the pathogenic principle of Toxoplasmagondiiand developing vaccines.