基于手性等离激元超表面的生化检测技术研究进展

Advances in Biochemical Detection Technology Based on Chiral Plasmonic Metasurfaces

超表面由亚波长尺度的人工微纳结构组成,可增强共振波长下光与物质的相互作用,并提高近场生化分子的信号强度。其中,手性等离激元超表面可稳定有效地增强手性分子的手性信号,有助于实现对痕量分子的检测。为满足生物、化学、环境等诸多领域对检测器件的高分辨率和高灵敏度要求,基于手性等离激元超表面的生化检测技术研究日益丰富。作者综述了手性等离激元超表面生化检测的机制及手性等离激元超表面的研究进展。在生化检测方面,作者介绍了手性等离激元超表面在环境介质检测、手性检测、荧光检测及表面增强拉曼检测中的典型应用。最后,作者对手性等离激元超表面在生化检测领域的应用前景进行了展望。

Metasurfaces are composed of sub-wavelength scale artificial nanostructures,which enhance the light-matter interaction at resonant wavelengths and improve the signal intensity from biochemical molecules in the near field.The chiral plasmonic metasurfaces can robustly and effectively enhance the chiral signal of chiral molecules and achieve the detection of trace molecules.The biochemical detection technology 67based on chiral plasmonic metasurfaces is increasingly studied to meet the requirements of high resolution and high sensitivity of detection devices in many fields such as biology,chemistry and environment.This review presented mechanism of biochemical detection of chiral plasmonic metasurfaces and the advances in chiral plasmonic metasurfaces.In terms of biochemical detection,the recent progress in chiral plasmonic metasurfaces of environmental media sensing,chirality detection,fluorescence detection and surface-enhanced Raman detection was introduced.Finally,the review discussed the application prospect of chiral plasmonic metasurfaces in biochemical detection field.