基于VOSviewer和CiteSpace的中医补肾法研究热点与前沿可视化分析

Visualization analysis on the research hotspots and frontiers of TCM kidney tonifying methods based on VOSviewer and CiteSpace

目的运用文献计量学方法分析中医补肾法的知识基础和研究热点前沿,为临床研究提供参考。方法检索Web of Science核心合集数据库建库至2023年11月27日中医补肾法相关文献。采用VOSviewer 1.6.18软件绘制作者共现图,采用CiteSpace 6.1.R6软件对机构、作者、关键词、文献共被引等进行共现、聚类和突现分析,绘制网络图谱。结果纳入文献522篇,来源期刊174种,发文量最多的期刊和机构分别是J Ethnopharmacol(58篇)和广州中医药大学(49篇)。最大的合作团队是以河南中医药大学的李建生教授、李素云教授为代表的团队。频次排名前3位的关键词依次为extract、mechanism和apoptosis。关键词聚类分析显示,该领域研究主要集中在治疗病种和方法层面。结论中医补肾法的知识基础集中在网络药理学、转录组学分析、肠道菌群研究等技术方法,以及非酒精性脂肪肝、生精功能障碍、卵巢早衰、纤维化等疾病。研究热点集中在绝经后骨质疏松症、AD、COPD等疾病,网络药理学和分子对接等方法,以及山茱萸、中药提取物、炎症等方面。槲皮素、分子对接、NF-κB、安全性可能是其研究热点前沿。

Objective To analyze the knowledge foundation and research hotspots and frontiers of TCM kidney tonifying methods using bibliometric methods;To provide reference for clinical research.Methods Literature related yo TCM kidney-tonifying methods was retrieved from the Web of Science core collection database from the establishment of the database to November 27,2023.VOSviewer 1.6.18 was used to draw an author co-occurrence map.CiteSpace 6.1.R6 was used to conduct co-occurrence,clustering,and prominence analysis on institutions,authors,keywords,and literature co citation,and a network graph was drawn.Results 522 articles were included and published in 174 journals.The most widely published journals and institutions were J Ethnopharmacol(58 articles)and Guangzhou University of Chinese Medicine(49 articles).The largest collaborative team was represented by Professor Li Jiansheng and Professor Li Suyun from Henan University of Chinese Medicine.The top three high-frequency keywords were extract,mechanism,and apoptosis.Clustering analysis showed that research in this field mainly focused on the treatment of diseases and methods.Conclusion The knowledge foundation of TCM kidney tonifying methods focuses on technical methods such as network pharmacology,transcriptomics analysis,and gut microbiota research,as well as non-alcoholic fatty liver disease,spermatogenic dysfunction,premature ovarian failure,fibrosis,and other diseases.Research hotspots focus on diseases such as postmenopausal osteoporosis,Alzheimer disease,chronic obstructive pulmonary disease,network pharmacology and molecular docking methods,Corni Fructus,TCM extracts,inflammation,etc.Quercetin,molecular docking,NF-κB,and security may be at the frontier of its research hotspots.