富血小板血浆联合米诺地尔治疗雄激素性脱发患者的效果

Effects of platelet-rich plasma combined with Minoxidil in treatment of patients with androgenic alopecia

目的:观察富血小板血浆(PRP)联合米诺地尔治疗雄激素性脱发(AGA)患者的效果。方法:回顾性分析2019年11月至2023年1月该院收治的98例AGA患者的临床资料,按照治疗方法不同将其分为对照组和观察组各49例。对照组采用米诺地尔治疗,观察组在对照组基础上联合PRP治疗,两组均治疗4个月。比较两组临床疗效,治疗前后毛发镜指标(毳毛比例、单根毛发毛囊比例、毛发密度、毛囊密度)水平、性激素(睾酮、雌二醇、睾酮/雌二醇比值)水平、血清学指标[胰岛素样生长因子-1(IGF-1)、血管内皮生长因子(VEGF)、白细胞介素-33(IL-33)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.92%(47/49),高于对照组的83.67%(41/49),差异有统计学意义(P<0.05);治疗后,观察组毳毛比例、单根毛发毛囊比例低于对照组,毛发密度、毛囊密度高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组雌二醇水平高于对照组,睾酮水平、睾酮/雌二醇比值低于对照组,差异均有统计学意义(P<0.05);治疗后,观察组VEGF、IGF-1水平高于对照组,IL-33水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:PRP联合米诺地尔治疗AGA患者可提高治疗总有效率,改善毛发镜指标和血清学指标水平,调节性激素水平,效果优于单纯米诺地尔治疗。

Objective:To observe effects of platelet-rich plasma(PRP) combined with Minoxidil in treatment of patients with androgenetic alopecia(AGA).Methods:The clinical data of 98 patients with AGA admitted to the hospital from November 2019 to January 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,49 cases in each group.The control group was treated with Minoxidil,while the observation group was treated with PRP on the basis of that of the control group.Both groups were treated for 4 months.The clinical efficacy,the trichoscopy indexes(vellus hair ratio,single hair follicle ratio,hair density,hair follicle density) levels,the sex hormones(testosterone,estradiol,testosterone/estradiol) levels,the serological indexes [insulin-like growth factor-1(IGF-1),vascular endothelial growth factor(VEGF),interleukin-33(IL-33)] levels before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.92%(47/49),which was higher than 83.67%(41/49)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the vellus hair ratio and the single hair follicle ratio in the observation group were lower than those in the control group,the hair density and the hair follicle density were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of estradiol in the observation group was higher than that in the control group,the levels of testosterone and testosterone/estradiol were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of VEGF and IGF-1 in the observation group were higher than those in the control group,the level of IL-33 was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:PRP combined with Minoxidil in the treatment of the AGA patients can improve the total effective rate of treatment,improve the levels of trichoscopy indexes and serological indexes,and regulate the levels of sex hormones.Moreover,it is superior to simple Minoxidil treatment.