尼卡地平联合甲磺酸酚妥拉明治疗妊娠期高血压患者的效果

Effects of Nicardipine combined with Phentolamine mesylate in treatment of patients with gestational hypertension

目的:观察尼卡地平联合甲磺酸酚妥拉明治疗妊娠期高血压患者的效果。方法:选取2021年2月至2023年2月该院收治的92例妊娠期高血压患者进行前瞻性研究,按随机数字表法将其分为研究组和对照组各46例。对照组予以甲磺酸酚妥拉明治疗,研究组在对照组基础上联合尼卡地平治疗。比较两组临床疗效,治疗前后血压(收缩压、舒张压)、凝血功能指标[凝血酶原时间(PT)、纤维蛋白原(FIB)]、血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)]水平,以及不良反应发生率。结果:研究组治疗总有效率为91.30%(42/46),高于对照组的71.74%(33/46),差异有统计学意义(P<0.05);治疗后,两组收缩压、舒张压水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组PT均长于治疗前,且研究组长于对照组,两组FIB水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组NO水平均高于治疗前,且研究组高于对照组,两组ET-1水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:尼卡地平联合甲磺酸酚妥拉明治疗妊娠期高血压患者可提高治疗总有效率,改善凝血功能指标和血管内皮功能指标水平,降低血压水平,其效果优于单纯甲磺酸酚妥拉明治疗。

Objective:To observe effects of Nicardipine combined with Phentolamine mesylate in treatment of patients with gestational hypertension.Methods:A prospective study was conducted on 92 patients with gestational hypertension admitted to this hospital from February 2021 to February 2023.According to the random number table method,they were divided into study group and control group,46 cases in each group.The control group was treated with Phentolamine mesylate,while the study group was treated with Nicardipine on the basis of that of the control group.The clinical efficacy,the levels of blood pressure(systolic blood pressure,diastolic blood pressure) levels,the coagulation function indexes [prothrombin time(PT),fibrinogen(FIB)],and the vascular endothelial function indexes [nitric oxide(NO),endothelin-1(ET-1)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 91.30%(42/46),which was higher than 71.74%(33/46) in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The PT of the two groups was longer than that before the treatment,and that in the study group was longer than that in the control group;the FIB levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of NO in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;the levels of ET-1 in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Nicardipine combined with Phentolamine mesylate in the treatment of the patients with gestational hypertension can improve the total effective rate of treatment,improve the levels of coagulation function indexes and vascular endothelial function indexes,and reduce the levels of blood pressure indexes.Moreover,it is superior to single Phentolamine mesylate treatment.