金振口服液联合阿奇霉素治疗肺炎支原体肺炎患儿的效果

Effects of Jinzhen oral liquid combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia

目的:观察金振口服液联合阿奇霉素治疗肺炎支原体肺炎(MPP)患儿的效果。方法:选取2020年2月至2022年2月该院收治的90例MPP患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各45例。对照组给予阿奇霉素治疗,观察组在对照组基础上联合金振口服液治疗,比较两组临床疗效,治疗前后小气道功能指标[呼吸初期瞬间流量(FEF75%)、呼吸中期瞬间流量(FEF50%)、呼吸后期瞬间流量(FEF25%)]、血清学指标[血清Toll样受体4(TLR4)、T髓样分化因子88(MyD88)]、T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+))水平,以及不良反应发生率。结果:观察组治疗总有效率为88.89%(40/45),高于对照组的66.67%(30/45),差异有统计学意义(P<0.05);治疗后,两组FEF75%、FEF50%、FEF25%均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组TLR4、MyD88水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组CD3^(+)、CD4^(+)水平均高于治疗前,且观察组高于对照组,两组CD8^(+)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:金振口服液联合阿奇霉素治疗MPP患儿可提高治疗总有效率和小气道功能指标水平,改善T细胞亚群指标水平,以及降低血清学指标水平的效果优于单纯阿奇霉素治疗效果。

Objective:To observe effects of Jinzhen oral liquid combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia(MPP).Methods:A prospective study was conducted on 90 children with MPP admitted to this hospital from February 2020 to February 2022.According to the random number table method,they were divided into control group and observation group,45 cases in each group.The control group was treated with Azithromycin,while the observation group was treated with Jinzhen oral liquid on the basis of that of the control group.The clinical efficacy,the levels of small airway function indicators [forced expiratory flow after 75% of vital capacity has been expelled(FEF75%),forced expiratory flow after 50% of vital capacity has been expelled(FEF50%),forced expiratory flow after 25% of vital capacity has been expelled] levels,the serological indicators [serum Toll-like receptor 4(TLR4),T myeloid differentiation factor 88(MyD88)] and the T cell subsets indicators(CD3^(+),CD4^(+),CD8^(+)),and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 88.89%(40/45),which was higher than 66.67%(30/45) of the control group,and the difference was statistically significant(P<0.05).After the treatment,the FEF75%,FEF50% and FEF25% in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of TLR4 and MyD88 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CD3^(+) and CD4^(+) in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of CD8^(+) in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Jinzhen oral liquid combined with Azithromycin in the treatment of the children with MPP can improve the total effective rate of treatment and the levels of small airway function indicators,improve the levels of T cell subsets indicators,and reduce the levels of serological indicators.Moreover,it is superior to simple Azithromycin treatment.