桥本甲状腺炎患者甲状腺功能及生化指标变化情况分析

Analysis of Thyroid Function and Biochemical Indicator Changes of Patients with Hashimoto's Thyroiditis

目的:分析桥本甲状腺炎患者甲状腺功能及生化指标的变化。方法:选取2021年3月—2023年5月嘉峪关市第一人民医院收治的66例桥本甲状腺炎患者作为桥本组,选取同期66例健康体检者作为非桥本组。两组均进行甲状腺功能及生化指标检测,比较桥本组与非桥本组、桥本组不同疾病分期患者的甲状腺功能、生化指标水平。结果:桥本组游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平低于非桥本组,促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)、微小核糖核酸-454(miR-454)、可诱导共刺激分子(ICOS)、神经轴突导向分子SA(SemaSA)水平高于非桥本组,差异有统计学意义(P<0.05);两组表面细胞毒性T淋巴细胞相关抗原4(CTLA-4)水平比较,差异无统计学意义(P>0.05)。桥本组不同疾病分期患者FT_(3)、FT_(4)水平比较,甲状腺功能亢进期>甲状腺功能亢进和甲状腺功能减退并存期>甲状腺功能减退期,差异有统计学意义(P<0.05);桥本组不同疾病分期患者TSH、TgAb、TPOAb、miR-454、ICOS、SemaSA水平比较,甲状腺功能亢进期<甲状腺功能亢进和甲状腺功能减退并存期<甲状腺功能减退期,差异有统计学意义(P<0.05)。桥本组不同疾病分期患者CTLA-4水平比较,差异无统计学意义(P>0.05)。结论:桥本甲状腺炎患者多存在甲状腺功能异常,外周血miR-454、ICOS、SemaSA等生化指标呈高表达状态,且不同疾病分期桥本甲状腺炎患者甲状腺功能及生化指标水平存在差异,可为桥本甲状腺炎的诊断提供参考。

Objective:To analyze the thyroid function and changes in biochemical indicators of patients with Hashimoto's thyroiditis.Methods:A total of 66 patients with Hashimoto's thyroiditis admitted to Jiayuguan First People's Hospital between March 2021 and May 2023 were selected as the Hashimoto group,and 66 healthy individuals who underwent physical examinations during the same period were selected as the non-Hashimoto group.Both groups underwent thyroid function testing and biochemical indicator testing.The thyroid function and biochemical indicator levels between Hashimoto group and non-Hashimoto group and in patients at different disease stages in the Hashimoto group were compared.Results:The levels of free triiodothyronine(FT_(3))and free thyroxine(FT_(4))in the Hashimoto group were lower than those in the non-Hashimoto group,the levels of thyroid-stimulating hormone(TSH),anti-thyroglobulin antibody(TgAb),thyroid peroxidase antibody(TPOAb),microribonucleic acid-454(miR-454),inducible costimulatory molecule(ICOS)and neuronal axon guidance molecule SA(Sema SA)in the Hashimoto group were higher than those in the non-Hashimoto group,and the difference was statistically significant(P<0.05).There was no significant difference in the level of surface cytotoxic T lymphocyte-associated antigen 4(CTLA-4)between the two groups(P>0.05).The levels of FT_(3) and FT_(4) of patients at different disease stages in the Hashimoto group was ranked as hyperthyroidism stage>concurrent hyperthyroidism and hypothyroidism stage>hypothyroidism stage,and the difference was statistically significant(P<0.05).The levels of TSH,TgAb,TPOAb,miR-454,ICOS,and Sema SA of patients at different disease stages in the Hashimoto group were ranked as hyperthyroidism stage<concurrent hyperthyroidism and hypothyroidism stage<hypothyroidism stage,and the difference was statistically significant(P<0.05).There was no significant difference in CTLA-4 levels of patients at different disease stages in the Hashimoto group(P>0.05).Conclusion:Patients with Hashimoto's thyroiditis are often accompanied by abnormal thyroid function and high expression of biochemical indicators such as miR-454,ICOS and Sema SA in peripheral blood.In addition,there are significant differences in the thyroid function and biochemical indicator levels of patients with Hashimoto's thyroiditis at different disease stages.These findings can provide reference data for the diagnosis of Hashimoto's thyroiditis.