糖酵解代谢在妇科恶性肿瘤中的研究进展

Research progress of glycolytic metabolism in gynecological malignant tumors

肿瘤糖酵解代谢途径是近年来肿瘤机制和诊治研究的新热点。妇科恶性肿瘤的发病率和病死率较高,严重危害女性健康和生活质量。糖酵解能力增强与妇科肿瘤的生物学行为、放化疗、治疗耐受、恶性进展和不良预后密切相关。文章就糖酵解代谢在妇科主要恶性肿瘤中的研究进展进行综述,为妇科恶性肿瘤的机制探索、诊治研究和预后评估提供新的思路。

Abnormal glycolysis is a prominent feature of tumor cells,independent of oxygen availability.The metabolic pathway of tumor glycolysis has emerged as a significant focus in recent research on tumor mechanisms,diagnostics,and therapeutics.Gynecological malignancies exhibit high incidence and mortality rates,posing a significant threat to women's health and well-being.The heightened glycolytic capacity of these tumors is intricately linked to their biological behavior,response to radiotherapy and chemotherapy,treatment tolerance,malignant progression,and overall prognosis.Summarize the advancements in glycolysis metabolism research within major gynecological malignant tumors,offering novel insights for investigating mechanisms,diagnosing and treating these tumors,as well as evaluating prognosis.