血浆置换治疗高甘油三酯血症性急性胰腺炎的效果

Effect of Plasma Exchange in the Treatment of Hypertriglyceridemia Acute Pancreatitis

目的:探析血浆置换治疗高甘油三酯血症性急性胰腺炎的效果。方法:回顾性选取2018年3月—2023年3月深圳市龙岗区人民医院收治的128例高甘油三酯血症性急性胰腺炎患者。根据不同治疗方式将其分为对照组和观察组,各64例。两组均给予对症治疗,观察组在上述基础上给予血浆置换治疗。比较两组治疗前及治疗7 d后的相关指标、并发症及治疗前及治疗2 d、7 d后的急性生理与慢性健康状况评分(APACHEⅡ评分)。结果:治疗7 d后,两组甘油三酯(TG)、血清淀粉酶(AMY)、C反应蛋白(CRP)水平均降低,观察组TG、AMY、CRP水平均低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率为4.69%,低于对照组的18.75%,差异有统计学意义(P<0.05)。治疗2 d、7 d后,两组APACHEⅡ评分均降低,观察组APACHEⅡ评分低于对照组,差异有统计学意义(P<0.05)。结论:血浆置换治疗高甘油三酯血症性急性胰腺炎患者,能够改善其病情,降低并发症发生风险。

Objective:To explore the effect of plasma exchange in the treatment of hypertriglyceridemia acute pancreatitis.Method:A total of 128 patients with hypertriglyceridemia acute pancreatitis treated in Longgang District People's Hospital of Shenzhen from March 2018 to March 2023 were retrospectively selected.According to different treatment methods,they were divided into control group and observation group,64 cases in each group.Both groups were given symptomatic treatment,and the observation group was given plasma exchange therapy on the basis of the above.The relevant indicators before treatment and after 7 d of treatment,complications and acute physiological and chronic health scores(APACHEⅡscore)before treatment and after 2 d,7 d of treatment of the two groups were compared.Result:After 7 d of treatment,the levels of triglyceride(TG),serum amylase(AMY)and C-reactive protein(CRP)in both groups were decreased,and the levels of TG,AMY and CRP in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was 4.69%,which was lower than 18.75%in the control group,and the difference was statistically significant(P<0.05).After 2 d and 7 d of treatment,the APACHEⅡscore of both groups was decreased,and the APACHEⅡscore of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Plasma exchange therapy for patients with hypertriglyceridemia acute pancreatitis can improve the condition and reduce the risk of complications.