白眉蛇毒血凝酶辅助治疗非静脉曲张性上消化道出血的效果

Effect of Hemocoagulase in the Assisted Treatment of Non-variceal Upper Gastrointestinal Bleeding

目的:探讨白眉蛇毒血凝酶辅助治疗非静脉曲张性上消化道出血(non-variceal upper gastrointestinal bleeding,NVUGIB)的效果。方法:选取2022年2月—2023年2月松滋市中医医院收治的120例NVUGIB患者。随机将其分为对照组和观察组,各60例。两组均给予常规止血对症治疗,观察组在此基础上给予白眉蛇毒血凝酶辅助治疗。比较两组相关指标,治疗前后炎症因子、血液流变学指标,治疗效果及不良反应。结果:观察组输血量少于对照组,止血时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组C反应蛋白(C-reactive protein,CRP)及血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平均降低,观察组CRP、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组红细胞沉降率(erythrocyte sedimentation rate,ESR)降低,红细胞比容(packed cell volume,PCV)、全血高切黏度、全血低切黏度均增高,观察组ESR低于对照组,PCV、全血高切黏度、全血低切黏度均高于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:NVUGIB患者使用白眉蛇毒血凝酶辅助治疗效果良好,可有效减轻患者炎症反应,改善血液流变学,达到快速止血效果,减少输血量,不会增加患者不良反应。

Objective:To explore the effect of Hemocoagulase in the assisted treatment of non-variceal upper gastrointestinal bleeding(NVUGIB).Method:A total of 120 NVUGIB patients admitted to Songzi Traditional Chinese Medicine Hospital from February 2022 to February 2023 were selected.They were randomly divided into control group and observation group,60 cases in each group.Both groups were given routine symptomatic treatment for hemostasis,and the observation group was given assisted treatment with Hemocoagulase on this basis.The relevant indexes,inflammatory factors,hemorheology indexes before and after treatment,therapeutic effect and adverse reactions were compared between the two groups.Result:The blood transfusion volume in the observation group was less than that in the control group,and the hemostasis time was shorter than that in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in both groups decreased,and the levels of CRP and TNF-αin the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the erythrocyte sedimentation rate(ESR)decreased,while the packed cell volume(PCV),whole blood high tangential viscosity and whole blood low tangential viscosity increased in both groups,the ESR of the observation group was lower than that of the control group,PCV,whole blood high tangential viscosity,whole blood low tangential viscosity were higher than those in control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:NVUGIB patients with Hemocoagulase adjuvant treatment effect is good,can effectively reduce the inflammatory response of patients,improve hemorheology,achieve rapid hemostasis effect,reduce the amount of blood transfusion,will not increase the adverse reactions of patients.