桂枝芍药知母汤加减联合西药治疗对类风湿关节炎的影响

Effect of Guizhi Shaoyao Zhimu Decoction Addition and Subtraction Combined with Western Medicine Treatment on Rheumatoid Arthritis

目的:探讨桂枝芍药知母汤加减联合西药治疗对类风湿关节炎(rheumatoid arthritis,RA)的影响。方法:选取2021年1月—2022年5月麻城市人民医院收治的85例RA患者。根据随机数表法将其分为普通针刺组(F组,n=42)和桂枝芍药知母汤组(G组,n=43)。F组给予普通针刺联合西药治疗,G组给予桂枝芍药知母汤加减联合西药治疗。比较两组临床疗效,治疗前后相关指标、关节功能。结果:G组总有效率高于F组,差异有统计学意义(P<0.05)。治疗后,两组视觉模拟评分法(visual analogue scale,VAS)评分、类风湿因子(rheumatoid factor,RF)、程序性死亡受体配体1(programmed death ligand 1,PD-L1)水平均降低,G组VAS评分、RF、PD-L1水平均低于F组,差异有统计学意义(P<0.05)。治疗后,两组晨僵时间、关节肿胀数、关节压痛数均显著降低,G组晨僵时间、关节肿胀数、关节压痛数均低于F组,差异有统计学意义(P<0.05)。结论:桂枝芍药知母汤加减联合西药可以有效减轻患者的局部疼痛,改善RF水平,提高临床治疗效果。

Objective:To investigate the effect of Guizhi Shaoyao Zhimu Decoction addition and subtraction combined with western medicine treatment on rheumatoid arthritis(RA).Method:A total of 85 patients with RA admitted to Macheng People's Hospital from January 2021 to May 2022 were selected.According to random number table method,they were divided into ordinary acupuncture group(group F,n=42)and Guizhi Shaoyao Zhimu Decoction group(group G,n=43).Group F was treated with ordinary acupuncture combined with western medicine,group G was treated with Guizhi Shaoyao Zhimu Decoction combined with western medicine.The clinical efficacy,relevant indexes and joint function before and after treatment were compared between the two groups.Result:The total effective rate of group G was higher than that of group F,and the difference was statistically significant(P<0.05).After treatment,the visual analogue scale(VAS)score,rheumatoid factor(RF)and programmed death ligand 1(PD-L1)levels were decreased in both groups,the VAS score,RF and PD-L1 levels in group G were lower than those in group F,and the differences were statistically significant(P<0.05).After treatment,the morning stiffness time,joint swelling number and joint tenderness number of both groups were significantly decreased,the morning stiffness time,joint swelling number and joint tenderness number of group G were lower than those of group F,and the differences were statistically significant(P<0.05).Conclusion:Guizhi Shaoyao Zhimu Decoction combined with western medicine can effectively reduce patients'local pain,improve RF level and improve clinical treatment effect.