七氟烷复合右美托咪定用于腹腔镜下结直肠癌根治术中的麻醉效果

Anesthetic Effect of Sevoflurane Combined with Dexmedetomidine in Laparoscopic Radical Resection of Colorectal Cancer

目的:探究七氟烷复合右美托咪定用于腹腔镜下结直肠癌根治术中的麻醉效果。方法:选择2020年6月—2023年6月成武县人民医院接收的80例腹腔镜下结直肠癌根治术患者作为研究对象,根据随机数表法分为对照组、观察组,各40例。对照组接受丙泊酚麻醉,观察组接受七氟烷复合右美托咪定麻醉。比较两组镇静效果、血流动力学指标、不良反应发生率及舒适度。结果:麻醉前(T_(0)),两组Ramsay镇静评分、血流动力学指标比较,差异无统计学意义(P>0.05)。切皮时(T_(1))、切皮后10 min(T_(2))、手术完成时(T_(3)),两组Ramsay镇静评分高于T_(0),且观察组Ramsay镇静评分高于对照组,差异有统计学意义(P<0.05)。T_(0),两组血流动力学指标比较,差异无统计学意义(P>0.05);T_(1)~T_(3),对照组平均动脉压(MAP)、心率(HR)高于T_(0),且高于观察组,差异有统计学意义(P<0.05)。观察组不良反应发生率为5.00%,低于对照组的20.00%,差异有统计学意义(P<0.05)。麻醉后4 h,两组Kolcaba舒适状况量表(GCQ)中生理、心理精神、环境及社会文化评分均高于麻醉前,且观察组均高于对照组,差异有统计学意义(P<0.05)。结论:七氟烷复合右美托咪定可提高麻醉效果,稳定血流动力学指标,降低不良反应发生率,同时提高舒适度。

Objective:To explore the anesthetic effect of Sevoflurane combined with Dexmedetomidine in laparoscopic radical resection of colorectal cancer.Method:A total of 80 patients received laparoscopic radical resection of colorectal cancer in Chengwu County People's Hospital from June 2020 to June 2023 were selected as the study objects and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was anesthetized with Propofol,and the observation group was anesthetized with Sevoflurane combined with Dexmedetomidine.The effects of sedation,hemodynamic indexes,incidence of adverse reactions and comfort were compared between the two groups.Result:Before anesthesia(T_(0)),there were no significant differences in Ramsay sedation score and hemodynamic indexes between the two groups(P>0.05).At the time of skin resection(T_(1)),10 min after skin resection(T_(2))and the completion of surgery(T_(3)),the Ramsay sedation score of the two groups was higher than those of the T_(0),and the Ramsay sedation score of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).T_(0),there were no significant differences in hemodynamic indexes between the two groups(P>0.05).T_(1)-T_(3),the mean arterial pressure(MAP)and heart rate(HR)in the control group were higher than those in T_(0) and observation group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).At 4 h after anesthesia,the Kolcaba general comfort questionnaire(GCQ)scores of physiological,psychological,environmental and sociocultural scores in both groups were higher than those before anesthesia,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Sevoflurane combined with Dexmedetomidine can improve the anesthetic effect,stabilize the hemodynamic index,reduce the incidence of adverse reactions and improve the comfort level.