调脂汤联合阿托伐他汀对急性脑梗死患者的影响

Effect of Tiaozhi Decoction Combined with Atorvastatin on Carotid Atherosclerotic Plaque in Patients with Acute Cerebral Infarction

目的:分析调脂汤联合阿托伐他汀对急性脑梗死患者的影响。方法:选取2021年1月—2023年6月福建省福州神经精神病防治院和罗源县精神病防治院收治的90例急性脑梗死患者。根据随机数表法将其分为对照组和观察组,各45例。两组入院后均给予常规基础治疗,对照组给予阿托伐他汀治疗,观察组给予阿托伐他汀联合调脂汤治疗。比较两组治疗前后血液流变学指标、血脂指标、颈动脉粥样硬化斑块面积及颈动脉内膜中层厚度(IMT)、不良反应。结果:治疗后,观察组血小板聚集率、红细胞比容、红细胞聚集指数、血浆黏度及全血高切黏度均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)均低于对照组,高密度脂蛋白胆固醇(HDL-C)高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组颈动脉粥样硬化斑块面积及IMT值均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:急性脑梗死患者采用调脂汤联合阿托伐他汀治疗可促进其血液流变学及颈动脉粥样硬化斑块改善,而且不会增加用药后不良反应。

Objective:To analyze the effect of Tiaozhi Decoction combined with Atorvastatin in patients with acute cerebral infarction.Method:A total of 90 patients with acute cerebral infarction admitted to Fuzhou Neuropsychiatric Hospital in Fujian Province and Luoyuan County Psychiatric Hospital from January 2021 to June 2023 were selected.They were divided into control group and observation group according to random number table method,45 cases in each group.Both groups were given routine basic treatment after admission,the control group was given Atorvastatin treatment,and the observation group was given Atorvastatin combined with Tiaozhi Decoction treatment.Hemorheology index,blood lipid index,carotid atherosclerotic plaque area,carotid intima-media thickness(IMT)before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,the platelet aggregation rate,erythrocyte specific volume,erythrocyte aggregation index,plasma viscosity and whole blood high tangential viscosity in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,low density lipoprotein cholesterol(LDL-C),total cholesterol(TC)and triglyceride(TG)in observation group were lower than those in control group,high density lipoprotein cholesterol(HDL-C)was higher than that in control group,and the differences were statistically significant(P<0.05).After treatment,the carotid atherosclerotic plaque area and IMT value in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination treatment of Tiaozhi Decoction combined with Atorvastatin can improve the hemorheology and carotid atherosclerosis plaque in patients with acute cerebral infarction,and does not increase the adverse reactions after administration.