替罗非班氯化钠注射液联合介入治疗急性脑梗死患者的效果

Effect of Tirofiban Sodium Chloride Injection Combined with Interventional Therapy in Patients with Acute Cerebral Infarction

目的:探究替罗非班氯化钠注射液联合介入治疗急性脑梗死患者的临床效果。方法:选择2021年7月—2023年6月长江航运总医院收治的180例急性脑梗死患者作为研究对象,采用随机数表法将其分为试验组(n=90)和对照组(n=90)。对照组给予介入治疗,试验组在对照组基础上联合应用替罗非班氯化钠注射液治疗。比较两组治疗效果、神经功能缺损情况[美国国立卫生研究院卒中量表(NIHSS)]、凝血功能指标及不良事件发生情况。结果:试验组总有效率为95.56%,显著高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗前,两组NIHSS评分比较,差异无统计学意义(P>0.05);治疗后,两组NIHSS评分较治疗前降低,且试验组低于对照组,差异有统计学意义(P<0.05)。试验组不良事件发生率为22.22%,与对照组的33.33%比较,差异无统计学意义(P>0.05)。治疗前,两组凝血功能指标比较,差异无统计学意义(P>0.05);治疗后,两组凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)较治疗前长,且试验组长于对照组,差异有统计学意义(P<0.05)。结论:替罗非班氯化钠注射液联合介入治疗急性脑梗死效果显著,可改善凝血功能,减轻神经功损伤,同时也不会增加不良事件发生率。

Objective:To investigate the clinical effect Tirofiban Sodium Chloride Injection combined with interventional therapy in patients with acute cerebral infarction.Method:A total of 180 patients with acute cerebral infarction who admitted to General Hospital of the Yangtze River Shipping from July 2021 to June 2023 were selected as the study subjects,they were divided into the experimental group(n=90)and the control group(n=90)by random number table method.The control group was given interventional therapy,and the experimental group was treated with Tirofiban Sodium Chloride Injection on the basis of the control group.The therapeutic effect,neurological deficit[National Institute of Health stroke scale(NIHSS)],coagulation function indexes and adverse events were compared between two groups.Result:The total effective rate of the experimental group was 95.56%,which was significantly higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in NIHSS score between two groups(P>0.05);after treatment,the NIHSS scores of two groups were lower than those before treatment,and that in the experimental group was lower than that in the control group,the differences were statistically significant(P<0.05).The incidence of adverse events in the experimental group was 22.22%,compared with 33.33%in the control group,the difference was not statistically significant(P>0.05).Before treatment,there were no significant differences in the coagulation function indexes between two groups(P>0.05);after treatment,the thrombin time(TT),prothrombin time(PT)and activated partial thromboplastin time(APTT)of two groups were longer than those before treatment,and those in the experimental group were longer than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Tirofiban Sodium Chloride Injection combined with interventional therapy in patients with acute cerebral infarction has a significant effect,which can improve coagulation function,reduce nerve function damage,and will not increase the incidence of adverse events.