癫痫与偏头痛共病的研究进展

Research progress of comorbidity of epilepsy and migraine

癫痫及偏头痛是神经科常见的两种慢性发作性神经系统疾病,中枢高兴奋性或高反应性状态是二者病理生理学的基础。癫痫和偏头痛均有发作性、刻板性等临床特征,同时共享皮质扩布性抑制、离子通道异常等发病机制,二者经常共患且在治疗上存在共通之处,多种抗癫痫药物可用于预防偏头痛的发作。本文从流行病学、发病机制、易患因素、分类及诊断、治疗及预后等方面对癫痫共患偏头痛进行综述。

Epilepsy and migraine are two common chronic episodic neurological disorders in neurology,with central excitability or hyperresponsiveness being the basis of their pathophysiology.Epilepsy and migraine both have clinical characteristics such as episodic and stereotyped symptoms,and share the pathogenesis of cortical spreading inhibition and ion channel abnormalities.The two often share common symptoms and have similarities in treatment.Multiple antiepileptic drugs can be used to prevent migraine attacks.This article provides a review of comorbid migraines with epilepsy from the perspectives of epidemiology,pathogenesis,susceptibility factors,classification and diagnosis,treatment,and prognosis.