硫酸沙丁胺醇气雾剂与茶碱缓释片治疗急诊老年哮喘的临床效果

Clinical efficacy of salbutamol sulfate aerosol and theophylline sustained-release tablets in the emergency treatment of elderly asthma

目的 探讨硫酸沙丁胺醇气雾剂与茶碱缓释片治疗急诊老年哮喘的临床效果。方法 80例急诊老年哮喘患者,应用计算机随机数字表法将所有患者分成常规组与联合组,每组40例。常规组患者使用硫酸沙丁胺醇气雾剂吸入治疗,联合组患者采用硫酸沙丁胺醇气雾剂吸入治疗联合茶碱缓释片口服治疗。比较两组患者治疗前后第1秒用力呼气容积、炎性因子[白细胞介素(IL)-4、IL-13、γ-干扰素(IFN-γ)]水平以及临床疗效、不良反应发生率。结果 治疗4、8周,两组组患者第1秒用力呼气容积均高于治疗前,联合组第1秒用力呼气容积分别为(2.47±0.21)、(2.62±0.17)L,均高于常规组的(2.03±0.23)、(2.16±0.11)L(P<0.05)。联合组临床总有效率90.00%高于常规组的67.50%(P<0.05)。治疗2、8周,两组患者IL-4、IL-13、IFN-γ水平均低于治疗前,联合组患者IL-4分别为(12.03±1.52)、(10.47±1.61)pg/ml,低于常规组的(15.98±1.47)、(12.69±1.63)pg/ml, IL-13分别为(195.26±21.69)、(182.36±27.98)pg/ml,低于常规组的(213.98±21.66)、(200.48±26.39)pg/ml, IFN-γ分别为(8.36±0.62)、(5.17±0.32)pg/ml,低于常规组的(10.47±0.69)、(7.69±0.36)pg/ml(P<0.05)。联合组不良反应发生率22.50%与常规组的17.50%比较,差异无统计学意义(P>0.05)。结论 硫酸沙丁胺醇气雾剂联合茶碱缓释片用于治疗急诊老年哮喘既有较好的安全性,还能提升抑制炎症反应、提升呼吸功能的作用。

Objective To explore the clinical effect of salbutamol sulfate aerosol and theophylline sustained-release tablets in the emergency treatment of elderly asthma.Methods 80 elderly asthmatic patients were selected.Using computer random number grouping method,they were divided into conventional group and combined group,with 40 cases per group.Patients in the conventional group was treated with salbutamol sulfate aerosol inhalation treatment,while patients in the combined group was treated with salbutamol sulfate aerosol inhalation and theophylline sustained-release tablets.The forced expiratory volume in one second,levels of inflammatory factors[interleukin(IL)-4,IL-13,gamma-interferon(IFN-γ)]before and after treatment,and clinical efficacy,and incidence of adverse reactions of the two groups were compared.Results After 4 and 8 weeks of treatment,the forced expiratory volume in one second in both groups was higher than that before treatment;the forced expiratory volume in one second in the combined group were(2.47±0.21)and(2.62±0.17)L,which were higher than(2.03±0.23)and(2.16±0.11)L in the conventional group(P<0.05).The total clinical effective rate of the combined group was 90.00%,which was higher than 67.50%of the conventional group(P<0.05).After 2 and 8 weeks of treatment,the levels of IL-4,IL-13 and IFN-γin both groups were lower than those before treatment;IL-4 levels in the combined group were(12.03±1.52)and(10.47±1.61)pg/ml,which were lower than(15.98±1.47)and(12.69±1.63)pg/ml in the conventional group;IL-13 levels in the combined group were(195.26±21.69)and(182.36±27.98)pg/ml,which were lower than(213.98±21.66)and(200.48±26.39)pg/ml in the conventional group;IFN-γlevels in the combined group were(8.36±0.62)and(5.17±0.32)pg/ml,which were lower than(10.47±0.69)and(7.69±0.36)pg/ml in the conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group(22.50%)and the conventional group(17.50%)(P>0.05).Conclusion Salbutamol sulfate aerosol combined with theophylline sustained-release tablets in emergency treatment of elderly patients with asthma has high safety,which can also alleviate inflammatory reactions and improve respiratory function.