加味酸枣仁汤对阴虚内热型2型糖尿病伴失眠患者疗效的影响分析

Effect analysis of modified Suanzaoren Decoction on the treatment of type 2 diabetes patients with insomnia of yin deficiency and internal heat type

目的分析加味酸枣仁汤在阴虚内热型2型糖尿病伴失眠患者中的应用价值。方法回顾分析68例2型糖尿病伴失眠患者,按照治疗方案不同,将患者分为对照组(34例)与干预组(34例)。两组患者在降糖治疗的基础上,对照组使用艾司唑仑片治疗,干预组患者使用加味酸枣仁汤治疗。比较两组患者血糖水平、睡眠状况、焦虑程度及失眠疗效。结果治疗后,两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白均明显降低,且干预组患者的空腹血糖(6.35±1.24)mmol/L、餐后2 h血糖(8.37±1.58)mmol/L、糖化血红蛋白(6.73±1.12)%低于对照组的(7.20±1.36)mmol/L、(9.55±1.67)mmol/L、(7.44±1.30)%(P<0.05)。治疗后,两组患者的匹兹堡睡眠质量指数(PSQI)和焦虑自评量表(SAS)评分均明显降低,且干预组患者的PSQI评分(6.83±1.26)分和SAS评分(34.50±4.33)分低于对照组的(7.59±1.45)、(37.47±5.20)分(P<0.05)。治疗后,干预组患者的失眠总有效率为97.06%,对照组为79.41%,干预组高于对照组(P<0.05)。结论加味酸枣仁汤治疗阴虚内热型2型糖尿病伴失眠患者效果更佳,有助于控制血糖水平,进一步改善睡眠质量和焦虑程度,具有推广价值。

Objective To analyze the practical value of modified Suanzaoren Decoction on the treatment of type 2 diabetes patients with insomnia of yin deficiency and internal heat type.Methods 68 cases of type 2 diabetes with insomnia were retrospectively analyzed.According to different treatment plans,they were divided into a control group(34 cases)and an intervention group(34 cases).On the basis of hypoglycemic treatment,the control group was treated with estazolam tablets,while the intervention group was treated with modified Suanzaoren Decoction.The blood glucose levels,sleep status,anxiety levels and insomnia efficacy were compared between two groups.Results After treatment,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in both groups were significantly reduced;the intervention group had fasting blood glucose of(6.35±1.24)mmol/L,2 h postprandial blood glucose of(8.37±1.58)mmol/L and glycosylated hemoglobin of(6.73±1.12)%,which were lower than(7.20±1.36)mmol/L,(9.55±1.67)mmol/L and(7.44±1.30)%in the control group(P<0.05).After treatment,the scores of Pittsburgh Sleep Quality Index(PSQI)and self-rating anxiety scale(SAS)were significantly reduced in both groups;the intervention group had PSQI score of(6.83±1.26)points and SAS score of(34.50±4.33)points,which were lower than(7.59±1.45)and(37.47±5.20)points in the control group(P<0.05).After treatment,the total effective rate of insomnia was 97.06%in the intervention group and 79.41%in the control group;the intervention group was higher than the control group(P<0.05).Conclusion Modified Suanzaoren Decoction is more effective in treating type 2 diabetes patients with insomnia of yin deficiency and internal heat type,which is helpful to control blood glucose level,further improve sleep quality and anxiety level,and has popularization value.