Siglec在肝移植免疫调控机制中的研究进展

Research progress of Siglec in immune regulatory mechanisms of liver transplantation

在各种免疫调节系统中,存在着一种表达于免疫细胞表面的跨膜受体,可选择性地发挥作用,即唾液酸结合免疫球蛋白样凝集素(Siglec)家族。抑制宿主T细胞抗原应答是诱导肝移植免疫耐受的关键因素,新近发现Siglec-15是重要的T细胞抑制分子,部分家族成员与其具有相似的结构及生物学特性,由此,推测Siglec家族的成员可能成为诱导肝脏免疫耐受的新靶点。该文对这一领域的相关文献进行综述,以Siglec-15为切入点,探讨Siglec家族在抑制宿主T细胞抗原应答及调控免疫反应中可能的作用和分子机制,为移植术后免疫调控和免疫耐受的建立提供新的思路。

In various immunomodulatory systems,there exists a transmembrane receptor expressed on the surface of immune cells,which can play a role selectively,namely the sialic-binding immunoglobulin-like lectin(Siglec)family.Inhibition of host T cell antigen response is a key factor in inducing immune tolerance of liver transplantation.Recently,Siglec-15 has been found to be an important T cell suppressor molecule,and some of its family members have similar structure and biological characteristics.It is speculated that the members of Siglec family may be a new target for inducing liver immune tolerance.Therefore,this paper reviews the relevant literatures in this field,and takes Siglec-15 as the entry point to explore the possible role and molecular mechanism of Siglec family in inhibiting host T cell antigen response and regulating immune response in order to provide the new ideas for the establishment of immune regulation and tolerance after transplantation.