侵袭性念珠菌病研究进展

Advances in research on invasive candidiasis

侵袭性念珠菌病(IC)是最常见的真菌感染性疾病,临床诊断困难,伴有极高的发病率和病死率,给危重症患者和免疫力低下的人群带来严重的负担.白假丝酵母是世界上大多数地区IC重点致病菌,但近年来,非白假丝酵母在一些国家和地区逐渐成为优势菌种,给临床治疗带来了极大的困难,本文综述了目前IC最新的流行病学研究进展,深入探讨IC在高危人群中的流行现状以及致病菌种的变化趋势,以期为IC的诊疗防治提供参考.

Invasive candidiasis(IC)is the most common fungal infectious disease,which is difficult to diagnose clinically,accompanied by very high morbidity and mortality,and poses a serious disease burden to critically ill patients and immunocompromised individuals.Candida albicans has been the major causative agent of IC in most parts of the world,but in recent years,non-Candida albicans has gradually become the dominant species in some countries and regions,which has brought great difficulties in clinical management.This article reviews the latest epidemiologic progress of IC,and discusses in depth the current epidemiologic status of IC in high-risk populations as well as the trend of causative species,with the aim of providing new theoretical basis for the diagnosis and prevention of IC.