穴位贴敷疗法联合沙美特罗替卡松粉吸入剂治疗慢性阻塞性肺疾病临床研究

Clinical Study on Point Application Therapy Combined with Salmeterol Assigned Powder Inhaler for Chronic Obstructive Pulmonary Disease

目的:观察穴位贴敷疗法联合沙美特罗替卡松粉吸入剂治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法:将104例COPD患者以随机数字表法分为研究组与对照组各52例。研究组以穴位贴敷疗法联合沙美特罗替卡松粉吸入剂治疗,对照组仅给予沙美特罗替卡松粉吸入剂治疗。比较2组临床疗效,比较2组治疗前后中医证候积分、呼吸困难程度、肺功能、炎症反应及免疫功能。结果:治疗后,研究组总有效率94.23%,高于对照组80.77%(P<0.05)。治疗后,2组中医证候积分、呼吸困难程度量表(mMRC)评分均降低(P<0.05),且研究组低于对照组(P<0.05)。治疗后,2组用力肺活量(FVC)、第1秒用力呼气容积占预计值百分比(FEV_(1)%)、FEV1/FVC均升高(P<0.05),且研究组高于对照组(P<0.05)。治疗后,2组血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均降低,且研究组低于对照组(P<0.05)。治疗后,研究组T淋巴细胞亚群CD4^(+)、CD4^(+)/CD8^(+)均升高(P<0.05),CD8^(+)降低(P<0.05);对照组治疗前后CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)值比较,差异均无统计学意义(P>0.05)。结论:穴位贴敷疗法联合沙美特罗替卡松粉吸入剂治疗COPD疗效显著,可缓解临床症状,减轻呼吸困难程度和炎症反应,改善肺功能及机体免疫功能。

Objective:To observe the clinical effect of point application therapy combined with Salmeterol assigned powder inhaler for chronic obstructive pulmonary disease(COPD).Methods:A total of 104 cases of patients with COPD were divided into the study group and the control group according to the random number table method,with 52 cases in each group.The study group was treated with point application therapy combined with Salmeterol assigned powder inhaler,and the control group was simply treated with Salmeterol assigned powder inhaler.The clinical effects were compared between the two groups;traditional Chinese medicine syndrome scores,dyspnea degree,lung function,inflammatory responses and immune function in the two groups were compared before and after treatment.Results:After treatment,the total effective rate was 94.23%in the study group,higher than that of 80.77%in the control group(P<0.05).After treatment,traditional Chinese medicine syndrome scores and dyspnea degree in modified Medical Research Council(mMRC)scores in the two groups were decreased(P<0.05),and the scores in the study group were lower than those in the control group(P<0.05).After treatment,forced vital capacity(FVC),the percentage of forced expiratory volume in the first second to the expected value(FEV1%)and FEV_(1)/FVC in the two groups were increased(P<0.05),and the indexes in the study group were higher than those in the control group(P<0.05).After treatment,the levels of interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in serum in the two groups were decreased,and the levels in the study group were lower than those in the control group(P<0.05).After treatment,the T lymphocyte subsets of CD4^(+)and CD4^(+)/CD8^(+)in the study group were increased(P<0.05),and CD8^(+)was decreased(P<0.05);there was no significant difference being found in the comparison of the values of CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)before and after treatment in the control group(P>0.05).Conclusion:Point application therapy combined with Salmeterol assigned powder inhaler has a significant curative effect in the treatment of COPD,which can alleviate clinical symptoms,reduce dyspnea and inflammatory responses,and improve lung function and immune function.