疏肝和胃理气类药物治疗胃食管反流病研究进展

Research Progress of Soothing Liver and Regulating Qi-flowing for Harmonizing Stomach Medicine in the Treatment of Gastroesophageal Reflux Disease

胃食管反流病病程绵长且易复发,治疗棘手,目前成因尚无法完全明晰。经现代药理研究及临床证实,疏肝和胃理气类中药如柴胡、木香、枳实、代代花等及其相关中药组方的作用机制可通过抑制胃酸分泌、抗炎作用、改善食管黏膜损伤、促进胃动力、改善食管下括约肌功能、保护胃黏膜,防治胃溃疡形成、缓解异常情绪、抗抑郁、焦虑等方面促进该病的治疗,且疗效经临床证实确切。

Gastroesophageal reflux disease has a long and recurrent course and is difficult to treat,and the causes are still not fully understood.Modern pharmacological studies and clinical studies have confirmed that the action mechanism of soothing liver and regulating qi-flowing for harmonizing stomach medicine,such as radix bupleuri,Costustoot,immature bitter orange,seville orange flower,etc.and their related Chinese medicine formulations can inhibit gastric acid secretion,anti-inflammatory effect,improve esophageal mucosal injury,promote gastric motile,improve the function of lower esophageal sphincter,and protect gastric mucosa.Prevention of gastric ulcer formation,relief of abnormal mood,anti-depression,anxiety and other aspects promote the treatment of the disease,and the curative effect has been confirmed by clinical practice.