双歧杆菌乳杆菌三联活菌片结合枸橼酸莫沙必利片对功能性消化不良患儿的临床效果探讨

Discussion on the Clinical Effect of Bifidobacterium Lactis Triple activated bacterial Tablets Combined with Mosapride Citrate Tablets on Children with Functional Dyspepsia

目的 探究临床应用双歧杆菌乳杆菌三联活菌片与枸橼酸莫沙必利片联合治疗功能性消化不良患儿的治疗效果。方法 方便选取莆田学院附属医院于2021年1月-2023年6月收治的165例功能性消化不良患儿为研究对象,以随机数表法分成3组,每组55例。甲组接受双歧杆菌乳杆菌三联活菌片治疗,乙组接受枸橼酸莫沙必利片治疗,联合组接受甲组和乙组药物联合治疗。对比3组患儿治疗效果、胃肠功能水平及不良反应发生情况。结果 联合组治疗总有效率为95.00%,高于甲组的77.50%和乙组的80.00%,差异有统计学意义(χ^(2)=4.949、3.960,P均<0.05)。治疗后,联合组胃肠功能水平改善效果优于甲组和乙组,差异有统计学意义(P均<0.05)。3组不良反应总发生率比较,差异无统计学意义(P均>0.05)。结论 联合双歧杆菌乳杆菌三联活菌片与枸橼酸莫沙必利片治疗,可有助于提高临床疗效,改善胃肠功能水平,具有一定的安全性。

Objective To investigate the therapeutic effect of clinical application of Bifidobacterium lactis triple-activated bacterial tablets and mosapride citrate tablets in the combined treatment of children with functional dyspep-sia.Methods A total of 165 children with functional dyspepsia admitted to the Affiliated Hospital of Putian College from January 2021 to June 2023 were conveniently selected as the study objects and divided into 3 groups with 55 cases in each group by random number table method.Group A was treated with Bifidobacterium lactis triple-activated bacterial tablets,group B was treated with mosapride citrate tablets,and the combined group was treated with a combi-nation of group A and group B drugs.The therapeutic effect,gastrointestinal function level and the occurrence of ad-verse reactions were compared among the three groups.Results The total effective rate of combined group was 95.00%,which was higher than 77.50%in group A and 80.00%in group B,and the differences were statistically sig-nificant(χ^(2)=4.949,3.960,both P<0.05).After treatment,the improvement effect of gastrointestinal function in com-bined group was better than that in group A and group B,and the differences were statistically significant(both P<0.05).There were no significant differences in the total incidence of adverse reactions among the three groups(both P>0.05).Conclusion Combining the treatment of Bifidobacterium lactis triple-activated bacterial tablets with mosapride citrate tablets may help to improve the clinical efficacy,improve the level of gastrointestinal function,and have a cer-tain degree of safety.