卡托普利舌下含服与硝酸甘油静脉滴注进行高血压急诊治疗的效果及对并发症的预防分析

Effectiveness of Sublingual Captopril and Intravenous Nitroglycerin Drip for Hypertensive Emergency Treatment and Analysis of Complication Pre⁃vention

目的 探讨卡托普利舌下含服与硝酸甘油静脉滴注在高血压急诊治疗中的疗效以及用药后对并发症的预防意义。方法 系统选取2021年9月-2023年9月济南市第一人民医院接诊的100例高血压急诊患者,按照随机数表法分为两组。对照组50例,采取硝酸甘油静脉滴注治疗,观察组50例,在对照组基础上联合舌下含服卡托普利治疗。对比两组患者治疗结果、血压和心率以及并发症发生率。结果 观察组临床治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者血压、心率水平对比,差异无统计学意义(P均>0.05);治疗后,观察组患者血压和心率水平更低,差异有统计学意义(P均<0.05);观察组并发症发生率2.00%低于对照组14.00%,差异有统计学意义(χ^(2)=4.891,P<0.05)。结论 静脉滴注硝酸甘油联合舌下含服卡托普利可明显提高临床治疗效果,并降低高血压患者的并发症发生率,具有较高临床价值。

Objective To investigate the efficacy of sublingual captopril and intravenous nitroglycerin drip in the emer-gency treatment of hypertension and the significance of prevention of complications after the use of the drug.Methods 100 cases systematically of hypertensive emergency patients in Jinan First People's Hospital from September 2021 to September 2023 were selected,and the grouping method was randomized table method.They were divided into two group,50 cases were in the control group and treated with nitroglycerin intravenous drip.In the observation group,50 cases were treated with sublingual captopril on the basis of the control group.Comparison of the two groups of treat-ment results,blood pressure and heart rate differences and complication rates were conduct.Results The clinical treat-ment efficiency of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);before treatment,the blood pressure and heart rate levels of the two groups of patients were com-pared,and the differences were not statistically significant(both P>0.05);after treatment,the blood pressure and heart rate levels of the patients of the observation group were lower,and the differences were statistically significant(both P<0.05);in comparison of the occurrence of complications between the two groups of patients,the observation group was 2.00%lower than that of the control group 14.00%,the difference was statistically significant(χ^(2)=4.891,P<0.05).Conclusion Intravenous nitroglycerin drip combined with sublingual captopril can significantly improve the clinical therapeutic effect and reduce the incidence of complications in hypertensive patients,which has high clinical value.