还原型谷胱甘肽联合异甘草酸镁治疗慢性乙肝的效果分析

Analysis of the Effect of Reduced Glutathione Combined with Magnesium Isoglycyrrhizinate in the Treatment of Chronic Hepatitis B

目的 分析慢性乙肝(Chronnic Hepatitis B, CHB)治疗中应用还原型谷胱甘肽+异甘草酸镁的影响。方法 随机选择2021年1月—2023年12月徐州矿务集团总医院收治的100例CHB患者为研究对象,以随机数表法分为对照组和观察组,各50例。对照组采用还原型谷胱甘肽治疗;观察组采用还原型谷胱甘肽+异甘草酸镁治疗。比较两组的治疗效果、肝功能、炎症指标、不良反应。结果 观察组治疗总有效率(94.00%)高于对照组(80.00%),差异有统计学意义(χ^(2)=4.332, P<0.05)。治疗后,观察组肝功能指标低于对照组,差异有统计学意义(P<0.05)。观察组C-反应蛋白、白细胞介素-6分别为(5.61±1.54)mg/L、(8.57±2.15)ng/L,低于对照组的(8.25±1.77)mg/L、(11.12±3.06)ng/L,差异有统计学意义(t=7.957、4.821,P均<0.05)。观察组不良反应发生率(10.00%)略高于对照组(6.00%),但差异无统计学意义(P>0.05)。结论 CHB治疗中,联用还原型谷胱甘肽、异甘草酸镁可促进改善患者肝功能,减轻机体炎症反应,提升疗效,且不会增加药物不良反应。

Objective To analyze the effect of application of reduced glutathione+magnesium isoglycyrrhizinate in the treatment of chronic hepatitis B(CHB).Methods 100 cases of CHB patients admitted to Xuzhou Mining Group General Hospital from January 2021 to December 2023 were randomly selected as the study subjects,and were di⁃vided into the control group and the observation group by random number table method,50 cases each.The control group was treated with reduced glutathione,and the observation group was treated with reduced glutathione+magne⁃sium isoglycyrrhizinate.The therapeutic effect,liver function,inflammation indexes,and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the observation group(94.00%)was higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=4.332,P<0.05).After treatment,the liver function indexe of the observation group was lower than that of the control group,and the difference was sta⁃tistically significant(P<0.05).The C-reactive protein and interleukin-6 of the observation group were(5.61±1.54)mg/L and(8.57±2.15)ng/L,respectively,which were lower than those of the control group(8.25±1.77)mg/L and(11.12±3.06)ng/L,and the differences were statistically significant(t=7.957,4.821,both P<0.05).The incidence of adverse reactions in the observation group(10.00%)was slightly higher than that in the control group(6.00%),but the differ⁃ence was not statistically significant(P>0.05).Conclusion In the treatment of CHB,the combination of reduced gluta⁃thione and magnesium isoglycyrrhizinate can promote the improvement of patients'liver function,reduce the body's inflammatory response,and enhance the therapeutic efficacy,and it will not increase the adverse effects of drugs.