育龄期女性社区获得性生殖道支原体感染状况及耐药分析

Status of Community-acquired Genital Mycoplasma Infection and Drug Resistance in Women of Childbearing Age

目的:分析育龄期女性社区获得性生殖道支原体感染状况及抗生素的耐药情况。方法:选取2020年12月—2021年5月雷州市人民医院门诊采集的900份社区育龄期女性生殖道分泌物作为研究对象,采用支原体试剂盒进行解脲脲原体(Uu)和人型支原体(Mh)培养并进行药敏实验,以每10岁为1个年龄段对研究对象进行分组并分析结果。结果:本研究900份社区育龄期女性生殖道分泌物标本中,支原体阳性的有453例,阳性率为50.33%;按年龄阶段分析,21~30岁育龄女性的支原体感染率最高,31~40岁次之;药敏结果显示,支原体对四环素类抗生素(强力霉素、美满霉素)、交沙霉素较为敏感,耐药率均低于10%,大环内酯类(红霉素、克拉霉素等)的耐药率均高于29%,喹诺酮类(左氧氟沙星、环丙沙星等)耐药率均高于47%。结论:育龄期女性支原体感染以Uu感染为主,21~40岁女性多,支原体对强力霉素、交沙霉素、美满霉素均较为敏感,在无条件做药敏实验的情况下,临床医生可优先考虑使用强力霉素、交沙霉素、美满霉素进行治疗。

Objective:To analyze the status of community-acquired genital mycoplasma infection and antibiotic resistance in women of childbearing age.Methods:900 samples of genital secretions of community women of childbearing age from December 2020 to May 2021 were collected in Outpatient Department of Leizhou City People’s Hospital.The Mycoplasma kit was used to carry out U.urealyticum(Uu)and Mycoplasma hominis(Mh)culture and conduct drug susceptibility experiments.The subjects were divided into groups based on the age group of 10 years,and the results of each group were analyzed and calculated.Results:Among 900 specimens of female reproductive tract secretions in the community,453 cases were positive for Mycoplasma,with a positive rate of 50.33%.According to age analysis,women of childbearing age of 21~30-year-old had the highest rate of Mycoplasma infection,followed by 31~40-year-old.The drug susceptibility results showed that mycoplasma was more sensitive to tetracycline antibiotics(doxycycline,minocycline)and josamycin,and the drug resistance rate was less than 10%.The drug resistance rate of Macrolides(erythromycin)quinolones(levofloxacin,ciprofloxacin,etc.)was higher than 29%,and the drug resistance rate of quinolones(levofloxacin,ciprofloxacin,etc.)was higher than 47%.Conclusion:Mycoplasma infections in women of childbearing age are mainly Uu infections.Most women aged 21~40 are sensitive to doxycycline,josamycin,and minocycline.Under conditions of unconditional drug susceptibility testing,the mycoplasma is more sensitive to doxycycline,josamycin,and minocycline.Clinicians can give priority to the use of doxycycline,josamycin,and minocycline for treatment.