基于CREB信号通路的脑卒中治疗中药研究进展

New advances in stroke therapy targeting the CREB signaling pathway and the potential for herbal interventions

cAMP反应元件结合蛋白(cAMP response element binding protein,CREB)是一种真核细胞生物核内蛋白质,在各种器官中广泛表达,其被激活后增加下游基因的转录活性,促进相关基因的表达。CREB在神经元中的功能与许多细胞内过程有关,如增殖、分化、生存、长期突触电位、神经发生和神经元可塑性。越来越多的研究结果证明,CREB功能影响脑卒中的发生和发展,具有作为防治脑卒中新靶点的巨大潜力,且部分中药及有效成分可以促进CREB的表达。因此,本文将梳理归纳CREB信号通路在脑卒中病理生理学中的作用以及调节CREB表达的中药及有效成分的研究进展,以期为未来天然药物防治脑卒中研发提供依据和参考。

cAMP response element binding protein(CREB)is an eukaryotic intranuclear protein widely expressed in a variety of organs,and its activation increases the transcriptional activity of downstream genes and promotes the expression of related genes.The neuronal function of CREB is related to many intracellular processes,such as proliferation,differentiation,survival,long-term synaptic potentials,neurogenesis and neuronal plasticity.Increasing evidence has demonstrated that CREB plays an important role in the stroke development and therefore,it may serve as a potential target for stroke therapy.Since some herbal medicines as well as their active ingredients regulate the CREB signaling,this article will summarize the role of CREB signaling pathway in stroke pathophysiology.The research progress of traditional Chinese medicine and its active ingredients modulating CREB activity will also be discussed,with the aim of providing the basis and reference for the future research and development of natural medicines against stroke.