药物纳米晶自稳定Pickering 乳液给药系统研究的关键问题

Key issues in the study of drug nanocrystals self-stabilized Pickeringemulsions as drug delivery system

药物纳米晶自稳定Pickering乳液(drug nanocrystals self-stabilized Pickering emulsion,DNSPE)是一种以药物自身纳米晶为稳定剂的新型Pickering乳液,近年来在药物递送领域的研究越来越多。本文在总结药物递送DNSPE研究现状的基础上,全面综述影响其构建的主要因素、性质与结构的表征方法、体内命运等关键问题的研究进展,并展望产业化前景,以期为深化DNSPE的全面研究,促进其在药物递送领域的应用提供参考。

Drug nanocrystals self-stabilized Pickering emulsion(DNSPE)is a novel Pickering emulsion with drug nanocrystals as the stabilizer.There are more and more researches on DNSPE in the field of drug delivery in recent years.On the basis of summarizing the research status of DNSPE used as drug delivery systems,this paper comprehensively reviewed the research progress of three key issues,such as the main factors affecting construction of DNSPE,characterization methods of properties and structures,and in vivo fate,and looked forward to the industrialization prospect,which is beneficial to deepen the comprehensive research of DNSPE and promote its application in the field of drug delivery.