内皮糖萼:脑血管病的潜在治疗靶点

Endothelial glycocalyx: a potential therapeutic target for cerebrovascular diseases

血脑屏障(blood-brain barrier,BBB)损伤是很多神经系统疾病的主要病理表现。糖萼(glycocalyx)是覆盖血管内皮细胞管腔侧的凝胶层,对BBB功能具有重要调节作用。然而,糖萼非常脆弱,在各种神经系统疾病中很易受损,导致BBB破坏。文章重点关注糖萼在脑血管病中的潜在作用、糖萼与BBB损伤相关的可能机制,并探讨了保护和恢复内皮糖萼的潜在治疗策略。

Blood brain barrier(BBB)injury is the main pathological manifestation of many neurological diseases.Glycocalyx is the gel layer covering the lumen side of vascular endothelial cells,which plays an important role in regulating BBB function.However,glycocalyx is very fragile and easily damaged in various neurological diseases,leading to BBB destruction.This article focuses on the potential role of glycocalyx in cerebrovascular disease,the possible mechanisms related to glycocalyx and BBB injury,and explores the potential therapeutic strategies for protecting and restoring endothelial glycocalyx.