放射性粒子植入治疗腹部转移癌

Interstitial implantation of radioactive seeds for treatment of abdominal metastases

目的评价125I放射性粒子植入治疗腹腔转移癌的可行性、疗效及治疗优势。方法回顾分析放射性粒子植入治疗的8例腹腔转移癌患者的临床资料。结果3例盆腔转移者中2例II级疼痛患者术后疼痛缓解,1例III级疼痛患者术后1周疼痛逐渐降至I级。1例患侧下肢水肿患者术后1月水肿完全消失。1例输尿管受压患者经输尿管支架植入后腰背部疼痛消失。3例会阴坠胀感患者至术后2月复查坠胀感消失。2例腹壁转移患者术后1天疼痛消失,转移病灶逐渐减小。胰周及腹膜后多发淋巴结转移病例术后复查肿大淋巴结消失。结论放射性粒子植入治疗腹腔转移癌可有效提高患者的生活质量。

Objective To assess the feasibility,efficacy,and therapeutic advantages of radioactive 125I seed implantation for the treatment of abdominal metastases.Methods The clinical data of eight patients with abdominal metastases treated with radioactive 125I seed implantation were retrospectively analyzed.Results Of the three pelvic metastasis cases,two patients with grade II pain had postoperative pain relief,and one patient with grade III pain had a gradual decrease in pain to grade I one week after surgery.One patient with lower extremity edema had complete disappearance of edema one month after surgery.The lumbar back pain disappeared after ureteral stent implantation in one patient with ureteral compression.In three patients with perineal drop sensation,the discomfort disappeared at the 2-month postoperative follow-up.In two patients with abdominal wall metastases,the pain disappeared one day after surgery,and the metastatic lesions gradually decreased in size.Postoperative re-evaluation of patients with multiple peripancreatic and retroperitoneal lymph node metastases showed the disappearance of lymph node enlargement.Conclusion Radioactive 125I seed implantation can effectively improve the life quality of patients with abdominal metastases.