女珍颗粒联合唑吡坦治疗围绝经期肝肾阴虚型失眠症的临床研究

Clinical study on Nuzhen Granules with zolpidem tartrate in treatment of Yin deficiency of liver and kidney

目的探讨女珍颗粒联合唑吡坦治疗围绝经期肝肾阴虚型失眠症的临床疗效。方法选取2021年1月—2023年3月河南中医药大学第一附属医院脑病科收治的失眠症患者100例,随机分为对照组(50例)和治疗组(50例)。对照组患者睡前口服酒石酸唑吡坦片,10 mg/次,1次/d。在对照组的基础上,治疗组患者口服女珍颗粒,6 g/次,3次/d。两组治疗7 d。观察两组患者临床疗效,比较治疗前后两组患者症状缓解时间,睡眠质量评定量表(SPIEGEL)评分和生活质量评估量表(QOL)评分,及血清白细胞介素-1β(IL-1β)、脑胶质性神经营养因子(GDNF)、激素皮质醇(COR)和5-羟色胺(5-HT)水平。结果治疗后,治疗组临床总有效率为98.00%,明显高于对照组(84.00%,P<0.05)。治疗后,治疗组症状缓解时间均明显早于对照组(P<0.05)。治疗后,两组患者SPIEGEL评分比治疗前明显降低,而QOL评分明显升高(P<0.05),且治疗组评分明显好于对照组(P<0.05)。治疗后,两组患者血清GDNF和5-HT水平明显升高,而COR和IL-1β水平明显降低(P<0.05),且治疗组血清因子水平明显好于对照组(P<0.05)。结论女珍颗粒联合唑吡坦治疗围绝经期肝肾阴虚型失眠症能促进深度睡眠,使炎性反应减弱,有效提升生活质量。

Objective To explore the clinical effect of Nuzhen Granules with zolpidem tartrate in treatment of Yin deficiency of liver and kidney.Methods Patients(100 cases)with Yin deficiency of liver and kidney in the First Affiliated Hospital of Henan University Chinese Medicine from January 2021 to March 2023 were randomly divided into control(50 cases)and treatment(50 cases)group.Patients in the control group were po administered with Zolpidem Tartrate Tablets,10 mg/time,once daily.Patients in the treatment group were po administered with Nuzhen Granules on the basis of the control group,6 g/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores of SPIEGEL and QOL,and the levels of GDNF,5-HT,COR and IL-1βin two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.00%,which was significantly higher than that of the control group(84.00%,P<0.05).After treatment,the time of symptom relief in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the SPIEGEL score in two groups was significantly lower than that before treatment,while the QOL score was significantly increased(P<0.05),and the score of the treatment group was significantly better than that of the control group(P<0.05).After treatment,the serum levels of GDNF and 5-HT were significantly increased,while the levels of COR and IL-1βwere significantly decreased in two groups(P<0.05),and the level of serum factors in the treatment group was significantly better than that in the control group(P<0.05).Conclusion Nuzhen Granules with zolpidem tartrate in treatment of Yin deficiency of liver and kidney can promote deep sleep,weaken inflammatory reaction and effectively improve the quality of life.