雷公藤多苷片联合曲安奈德口腔软膏治疗盘状红斑狼疮的临床研究

Clinical study on Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste in treatment of discoid lupus erythematosus

目的探讨雷公藤多苷片联合曲安奈德口腔软膏治疗盘状红斑狼疮的临床疗效。方法选取2021年1月—2023年5月唐山市人民医院收治的94例盘状红斑狼疮患者,根据随机数字表法将94例患者分为对照组和治疗组,各47例。对照组于早饭后、晚餐后涂抹曲安奈德口腔软膏,0.4 g/次,2次/d,涂抹后1 h内禁食禁饮。治疗组在对照组基础上饭后口服雷公藤多苷片,1~1.5 mg/kg,3次/d。两组持续治疗4周。比较两组临床疗效、主观疼痛程度、病灶面积和血清因子水平。结果治疗后,对照组总有效率为78.72%,治疗组总有效率为93.62%,组间比较差异显著(P<0.05)。治疗后,两组视觉模拟法(VAS)评分比治疗前小,病损面积显著缩小(P<0.05),且治疗组VAS评分比对照组更小,治疗组病损面积小于对照组(P<0.05)。治疗后,两组的血清白细胞介素-2(IL-2)水平高于治疗前,血清骨桥蛋白(OPN)、白细胞介素-6(IL-6)水平低于治疗前(P<0.05);治疗组的血清IL-2水平高于对照组,血清OPN、IL-6水平低于对照组(P<0.05)。结论雷公藤多苷片联合曲安奈德口腔软膏可提高盘状红斑狼疮的疗效,有助于减轻疼痛程度和缩小病损面积,减轻炎症反应。

Objective To investigate the curative effect of Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste in treatment of discoid lupus erythematosus.Methods Patients(94 cases)with discoid lupus erythematosus in Tangshan People’s Hospital from January 2021 to May 2023 were divided into control and treatment groups according to the random number table method,and each group had 47 cases.Patients in the control group were treated with Triamcinolone Acetonide Dental Paste after breakfast and dinner,0.4 mg/time,twice daily,abstained from food and drink within 1 h after application.Patients in the treatment group were po administered with Tripterygium Glycosides Tablets on the basis of the control group,1—1.5 mg/time,three times daily.Patients in two groups were treated for 4 weeks.The clinical efficacies,the subjective pain degree,lesion area,and serum factor levels in two groups were compared.Results After treatment,the total effective rate of the control group was 78.72%,but the total effective rate of the treatment group was 93.62%,and the difference between the groups was significant(P<0.05).After treatment,VAS score of two groups was smaller than before treatment,and the lesion area of two groups was significantly reduced(P<0.05),and the VAS score of the treatment group was smaller than that of the control group,and the lesion area of the treatment group was smaller than that of the control group(P<0.05).After treatment,the levels of IL-2 in two groups were higher than before treatment,but the levels of OPN and IL-6 in two groups were lower than before treatment(P<0.05).After treatment,the levels of IL-2 in the treatment group were higher than those in the control group,but the levels of OPN and IL-6 in the treatment group were lower than those in the control group(P<0.05).Conclusion Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste can improve the curative effect of discoid lupus erythematosus,help to reduce the degree of pain,lesion area,and inflammation.