基于加权TOPSIS法的银杏叶提取物注射液应用合理性评价

Evaluation of application rationality of Extract of Ginkgo Biloba Leaves Injection based on weighted TOPSIS method

目的 建立银杏叶提取物注射液药物利用评价细则,基于加权TOPSIS法对临床上使用银杏叶提取物注射液的合理性情况进行评价,为促进其在临床合理使用提供参考依据。方法 以银杏叶提取物注射液说明书、指南、共识以及相关文献为依据,制定银杏叶提取物注射液药物利用评价细则,采用加权TOPSIS法对亳州市人民医院2023年1-12月228份使用银杏叶提取物注射液病历进行评价。结果 228份病历中,合理病历(Ci≥0.8)有65例(28.51%),基本合理(0.6≤Ci<0.8)有125例(54.82%),不合理病历(Ci<0.6)有38例(16.67%)。不合理用药主要表现为给药疗程91例(39.91%)、滴注速度78例(34.21%)、相互作用52例(22.81%)、超医保限制适应证47例(20.61%)、超适应证31例(13.60%)、用药监护28例(12.28%)和用药前评估25例(10.96%)。结论 基于加权TOPSIS法的银杏叶提取物注射液合理性评价办法操作简单,具有可行性,评价结果更加直观合理。结果表明银杏叶提取物注射液临床使用较为不合理,医院需加强干预,以期促进临床合理使用。

Objective To establish the rules for evaluating the drug utilization of Extract of Ginkgo Biloba Leaves Injection,and to evaluate the rationality of clinical use of Extract of Ginkgo Biloba Leaves Injection based on weighted TOPSIS method,so as to provide a reference basis for promoting its rational use in the clinic.Methods Based on the instruction manual of Extract of Ginkgo Biloba Leaves Injection,guidelines,consensus and related literature,formulated the rules for the evaluation of drug utilization,and evaluated 228 medical records using it from January to December 2023 in Bozhou People’s Hospital by the weighted TOPSIS method.Results Among the 228 medical records,there were 65 cases(28.51%)of reasonable medical records(Ci≥0.8),125 cases(54.82%)of basically reasonable(0.6≤Ci<0.8),and 38 cases(16.67%)of unreasonable medical records(Ci<0.6).The main manifestations of irrational drug use included 91 cases(39.91%)of the course of administration,78 cases(34.21%)of infusion speed,52 cases(22.81%)of interaction,47 cases(20.61%)of exceeding the medical insurance limitation,31 cases(13.60%)of exceeding the indication,28 cases(12.28%)of medication monitoring,and 25 cases(10.96%)of pre-medication assessment.Conclusion The rationality evaluation approach of Extract of Ginkgo Biloba Leaves Injection based on the weighted TOPSIS method is simple and feasible,and the evaluation results are more intuitive and reasonable.The results showed that the clinical use of the drug is more unreasonable,and hospitals need to strengthen the intervention,with a view to promoting rational clinical use.