3类季铵盐的持续抗菌效果比较

Comparison of sustained antibacterial effect of three kinds of quaternary ammonium salts

目的研究3类单链季铵盐对白念珠菌的持续抗菌效果,为筛选抗菌产品提供理论支持。方法采用载体持续抗菌试验方法,对溴型、氯型和碳酸型3类季铵盐持续抗菌效果进行比较观察。结果溴型、氯型和碳酸型季铵盐均用活性物浓度为2000 mg/L,对载体上白念珠菌的持续抗菌时限分别达到95、95和59 d,在抗菌有效期限内仍可保持细菌减少率≥90%。溴型和氯型季铵盐抗菌效果持续时间明显长于碳酸型季铵盐。结论3类季铵盐均具有较好的持续抗菌作用,溴型和氯型季铵盐的持续抗菌效果更长。

Objective To study the sustained antibacterial effects of three single chain quaternary ammonium salts against Candida albicans and to provide theoretical support for screening antibacterial products.Methods The carrier sustained antibacterial test method was used to compare and observe the sustained antibacterial effects of three kinds of quaternary ammonium salts:bromine,chlorine,and carbonate.Results Bromine,chlorine,and carbonate quaternary ammonium salts were all used with an active substance concentration of 2000 mg/L,and their sustained antibacterial time against Candida albicans on the carrier reached 95,95,and 59 d,respectively.Within the antibacterial validity period,the bacterial reduction rate was still maintained at≥90%.The antibacterial effect of bromine and chlorine quaternary ammonium salts lasted longer than that of carbonate quaternary ammonium salts significantly.Conclusion All three kinds of quaternary ammonium salts have good sustained antibacterial effects,with bromine and chlorine quaternary ammonium salts having longer sustained antibacterial effects.