PI3K-AKT-mTOR信号通路在急性髓系白血病中的研究进展

Progress of PI3K-AKT-mTOR signaling pathway in acute myeloid leukemia

急性髓系白血病(AML)是一种造血干细胞恶性增殖的异质性疾病,其发病率和病死率不断上升,严重威胁人类的健康。近年研究表明PI3K-AKT-mTOR信号通路参与细胞中多种生物学过程的管理,其异常激活与肿瘤的发生和发展密切相关。文章就PI3K-AKT-mTOR信号通路在AML发生、发展与治疗中的最新研究进展进行综述。

Acute myelogenous leukemia(AML)is a heterogeneous disease characterized by malignant proliferation of hematopoietic stem cells,and its morbidity and mortality are increasing,which seriously threatens human health.In recent years,many studies have shown that PI3K-AKT-mTOR signaling pathway is involved in the management of various biological processes in cells,and its abnormal activation is closely related to the occurrence and development of tumors.Therefore,this article reviews the recent research progress of PI3K-AKT-mTOR signaling pathway in the pathogenesis,progression and treatment of AML.