组织标记夹置入在评估乳腺癌术前新辅助化疗疗效中的应用价值

The value of tissue marker clip placement in evaluating the efficacy of preoperative neoadjuvant chemotherapy for breast cancer

目的比较分析乳腺组织标记夹置入在X线评估乳腺癌新辅助化疗疗效及病理学检查中的应用价值。方法选取2022年10月到2023年10月徐州市中心医院80例确诊为乳腺癌并行术前新辅助化疗的患者作为研究对象,按是否置入乳腺组织标记夹分为标记夹组(22例)和非标记夹组(58例)。比较2组经X线复查乳腺原发病灶的检出率、新辅助化疗后X线评估与病理学评估的符合率以及术后标本送病理后到得到病理结果的耗时长短。结果2组患者在新辅助化疗完成后经X线复查乳腺原发病灶,标记夹组检出率为100%(22/22),非标记夹组检出率为56.9%(33/58),差异有统计学意义(P<0.05)。标记夹组在X线评估治疗效果的灵敏度、特异度、阳性预测值、阴性预测值及评估符合率均高于非标记夹组;在评估有无病灶残留的灵敏度、特异度、阳性预测值及评估符合率高于非标记夹组,阴性预测值低于非标记夹组。术后标本送达病理科到得到病理结果的耗时长短2组比较差异有统计学意义(P<0.05)。结论乳腺组织标记夹置入可能在提高X线对乳腺癌新辅助化疗疗效的评估水平及缩短病理诊断时长具有一定的价值。

Objective To compare and analyze the value of breast tissue marker clip placement in X-ray evaluation of the effect of neoadjuvant chemotherapy and pathological examination of breast cancer.Methods From October 2022 to October 2023,80 breast cancer patients undergoing neoadjuvant chemotherapy were selected from our hospital.They were divided into two groups based on whether a breast maker clip was placed:the marker clip group(n=22)and the non-marker clip group(n=58).The detection rates of primary breast lesions through X-ray re-examination,the coincident rate of X-ray evaluation and pathology evaluation after neoadjuvant chemotherapy,and the time-consuming of sending specimens to pathology after operation were compared between the two groups.Results After the completion of neoadjuvant chemotherapy,the detection rate of primary breast lesions was 100%(22/22)in the marker clip group and 56.9%(33/58)in the non-marker clip group,there was significant difference between the two groups(P<0.05).In the therapeutic effect of evaluated at X-ray,the sensitivity,specificity,positive predictive value,negative predictive value and assess compliance rate of the marker clip group were higher than those of the non-marker clip group;In the assessment of residual disease,the sensitivity,specificity,positive predictive value and assess compliance rate of the marker clip group were higher,and the negative predictive value was lower than those in the non-marker clip group.There was a significant difference between the two groups in the time it took for the specimens to reach the pathological results(P<0.05).Conclusion Breast marking clip placement may be of some value in improving the X-ray evaluation of neoadjuvant chemotherapy for breast cancer and shortening the time of pathological diagnosis.