摘要
红景天苷是从藏药红景天根及根茎中提取的活性成分,在现代研究中发现其具有抗炎、抗氧化、调节免疫,以及保护重要脏器血管的作用。血管舒缩功能障碍是血管类疾病诊断中的常见症状,也是此类疾病继续发展的重要原因。中药在防治血管舒缩功能障碍方面具有一定的优势,其中,红景天中的有效成分红景天苷对血管张力调节具有良好作用。本文通过内皮依赖性途径和非内皮依赖性途径对红景天苷影响血管舒缩状态的机制研究展开综述,为进一步研究红景天苷防治血管舒缩功能障碍提供理论依据。
Salidroside is an active ingredient extracted from the roots and rhizomes of Hongjingtian,a Tibetan medicine.In modern studies,it has been found that it has anti-inflammatory,antioxidant,immune regulation,and protection of important organs and blood vessels.Vasomotor dysfunction is a common symptom in the diagnosis of vascular diseases and an important reason for the development of such diseases.Traditional Chinese medicine has certain advantages in preventing and treating vasomotor dysfunction.Among them,salidroside,an effective component of Hongjingtian,has a good effect on vascular tension regulation.In this paper,the mechanism of salidroside's effect on vasomotor status through endothelium-dependent and non-endotheliumdependent pathways was reviewed to provide theoretical basis for further study of salidroside's prevention and treatment of vasomotor dysfunction.
作者
陈洁
王小博
孟宪丽
陈小睿
CHEN Jie;WANG Xiao-bo;MENG Xian-li;CHEN Xiao-rui(School of Pharmacy/School of Modern Chinese Medicine Industry,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan;Innovative Institute of Chinese Medicine and Pharmacy/Academy for Interdiscipline,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,Sichuan)
出处
《中药与临床》
2024年第2期96-100,共5页
Pharmacy and Clinics of Chinese Materia Medica
基金
国家自然科学基金(82104533和82274207)
成都中医药大学“杏林学者”学科人才科研提升计划项目(XKTD2022013)
宁夏回族自治区重点研发计划项目(2023BEG02012)。
关键词
血管舒缩功能障碍
红景天苷
血管内皮细胞
血管平滑肌细胞
作用机制
Vasomotor dysfunction
salidroside
vascular endothelial cells
vascular smooth muscle cells
mechanism of action