摘要
MmpL(Mycobacterial membrane protein large,MmpL)蛋白是结核分枝杆菌的一类重要外排泵转运蛋白,主要参与底物转运,也能介导耐药发生,是潜在的抗结核靶点。本文从MmpL蛋白的结构与功能、耐药机制、蛋白抑制剂等方面进行综述,旨在为MmpL蛋白的功能研究及分枝杆菌的新药研发提供参考建议。
Mycobacterial membrane protein large(MmpL)is an important type of efflux pump transporter in Mycobacterium tuberculosis that involves substrate transport and antibiotic resistance,thus being a potential target for anti-tuberculosis.The structure,function,antibiotic resistance and inhibitors of the MmpL proteins were reviewed with the purpose of providing suggestions for exploration of MmpL function and the development of new antimycobacteria agents.
作者
崔嘉伟
豆梁丁
赵西林
王岱
Cui Jiawei;Dou Liangding;Zhao Xilin;Wang Dai(Department of Experimental Medicine,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Xiamen University,Xiamen 361102)
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2024年第6期601-610,共10页
Chinese Journal of Antibiotics
基金
深圳市科技研发资金(No.JCYJ20220530143409021)。
关键词
分枝杆菌
MmpL蛋白
耐药机制
蛋白抑制剂
Mycobacterium tuberculosis
MmpL protein
Antibiotic resistance
Protein inhibitor
