发泡法与自体表皮细胞移植治疗面颈部白癜风美学效果的比较研究

Comparison of suction blister transplantation and noncultured autologous suspension of epidermal cells in treatment of stable vitiligo in the face and neck region

目的探讨发泡法移植技术与非培养自体表皮细胞移植再生技术在面颈部稳定期白癜风外科治疗的差异与美学意义。方法2016年5月至2020年5月,北京协和医院整形美容外科与南京华厦白癜风医院治疗面颈部稳定期白癜风患者64例,男25例、女39例;年龄10~46岁,平均25岁。随机数字表法分为发泡法移植组和自体表皮移植组,每组32例;分别于术后3个月和6个月计算两组患者的治疗有效率、色素沉着、拼缝畸形出现情况。结果发泡法移植组:治疗后3个月有效22例(68.75%),6个月有效29例(90.63%);自体表皮移植组:治疗后3个月有效19例(59.37%),6个月有效28例(87.50%);两组比较差异无统计学意义(P>0.05)。自体表皮移植组在术后3个月及6个月未出现色素沉着及拼缝畸形患者,效果优于发泡法移植组。结论非培养自体表皮细胞移植再生技术治疗白癜风更符合患者的美学需求。

Objective To evaluate the differences and aesthetic meaning of stable vitiligo treatment in the face and neck region using suction blister transplantation or noncultured autologous suspension of epidermal cells.Methods Sixty-four stable vitiligo patients(25 males and 39 females with age ranges from 10 to 46 years,average 25 years)in the face and neck region were randomly divided into two groups(32 patients in each group):one group received suction blister transplantation,while other group received noncultured autologous suspension of epidermal cells.Patients′treatment effectiveness,pigmentation and piecing deformity were evaluated in postoperative 3 months and 6 months.Results In the postoperative 3 months and 6 months,the effectiveness of suction blister transplantation group was 68.75%(22/32)and 90.63%(29/32),respectively,while the effectiveness of noncultured autologous suspension of epidermal cells group was 59.37%(19/32)and 87.50%(28/32),respectively,in which no significant differences were found between two groups(P>0.05).No obvious pigmentation and piecing deformity were found in noncultured autologous suspension of epidermal cells group,which were much better than the suction blister transplantation group in postoperative 3 months and 6 months.Conclusions Both suction blister transplantation and noncultured autologous suspension of epidermal cells could bring good treatment effectiveness for patients of stable vitiligo in the face and neck region.Compared with suction blister transplantation,noncultured autologous suspension of epidermal cells could offer better aesthetic appearance.