安胃疡胶囊辅助铋剂四联方案治疗HP阳性消化性溃疡的效果

Effect of Anweiyang Capsule Assisted Bismuth Quadruple Regimen in the Treatment of HP Positive Peptic Ulcer

目的:探讨安胃疡胶囊联合铋剂四联方案对幽门螺杆菌(HP)阳性消化性溃疡患者的治疗价值。方法:将2022年12月—2023年7月谷城县人民医院诊治的104例HP阳性消化性溃疡患者分为对照组和试验组,各52例。对照组予以铋剂四联方案治疗,试验组予以安胃疡胶囊联合铋剂四联方案治疗,比较两组总体疗效、HP根除率、氧化应激、炎症反应指标。结果:经2周治疗后,试验组总有效率为92.31%,高于对照组的76.92%(P<0.05);试验组HP根除率为84.62%,高于对照组的67.31%(P<0.05);试验组血清丙二醛(MDA)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、超敏-C反应蛋白(hs-CRP)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。结论:安胃疡胶囊联合铋剂四联方案治疗HP阳性消化性溃疡能增强疗效,提高HP根除率,并可降低氧化应激及炎症反应指标水平。

Objective:To explore the therapeutic value of Anweiyang capsule combined with bismuth quadruple regimen in patients with Helicobacter pylori(HP)positive peptic ulcer.Methods:A total of 104 patients with HP positive peptic ulcer diagnosed and treated in Gucheng County People’s Hospital from December 2022 to July 2023 were divided into control group and experimental group,with 52 patients in each group.The control group was treated with bismuth quadruple therapy,and the experimental group was treated with Anweiyang capsule combined with bismuth quadruple therapy.The overall efficacy,HP eradication rate,oxidative stress and inflammatory response indexes of the two groups were compared.Results:After 2 weeks of treatment,the total effective rate of the experimental group was 92.31%,which was higher than 76.92%of the control group(P<0.05).The eradication rate of HP in the experimental group was 84.62%,which was higher than 67.31%in the control group(P<0.05).The levels of serum malondialdehyde(MDA),lipid peroxide(LPO),superoxide dismutase(SOD),high-sensitivity C-reactive protein(hs-CRP),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in the experimental group were lower than those in the control group(P<0.05).Conclusion:Anweiyang capsule combined with bismuth quadruple regimen in the treatment of HP positive peptic ulcer can enhance the curative effect,improve the eradication rate of HP,and reduce the levels of oxidative stress and inflammatory response indexes.