根尖周病中程序性细胞死亡的研究进展

Research progress on programmed cell death in periapical periodontitis

程序性细胞死亡(PCD)是由基因决定的细胞主动、有序的死亡方式,其与根尖周病的进展密切相关。目前在根尖周病灶中发现的PCD途径有细胞凋亡、自噬、坏死性凋亡、细胞焦亡和铁死亡等。这些途径能被内源性和外源性刺激激活,在维持机体稳态和炎症调节中发挥重要作用。本文针对各种PCD途径在根尖周病中的作用进行综述,以期探究根尖周病的发病机制和靶向调控分子,从而为防治根尖周病提供新思路。

Programmed cell death(PCD)is a genetically determined,active,and orderly way of cell death,closely associated with the progression of periapical diseases.Various PCD pathways have been identified in periapical lesions,including apoptosis,autophagy,necroptosis,pyroptosis,and ferroptosis.These pathways can be activated by both endogenous and exogenous stimuli,playing crucial roles in maintaining homeostasis and regulating inflammation.This article provided a comprehensive review of the roles of different PCD pathways in periapical diseases,aiming to explore the pathogenesis and target regulatory molecules of periapical diseases,thereby offering new insights into their prevention and treatment.