贫血合并癌症患者的血液学变化及危险因素分析

Hematological Changes and Risk Factors in Patients with Anemia and Cancer

目的探究贫血合并癌症患者的血液学变化及危险因素。方法回顾性分析商丘市第三人民医院2022年1月—2023年12月收治的78例贫血且疑似肿瘤患者的临床资料,依据手术病理结果,将患者分为癌症组、非癌症组。对比癌症组与非癌症组患者的血常规指标、生化指标、肿瘤标记物。运用多因素logistic回归模型分析,确定各指标在对癌症的预测价值。结果78例患者中,癌症组24例(30.77%),非癌症组54例(69.23%)。癌症组患者中,消化道肿瘤17例(70.83%)。癌症组与非癌症组患者的血红蛋白(Hb)、红细胞分布宽度(RDW)、中性粒细胞比率(NEU)、白细胞计数(WBC)、中性粒细胞绝对值(ANC)、血小板分布宽度(PDW)比较,差异有统计学意义(P<0.05)。癌症组与非癌症组患者的丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、总蛋白(TP)、乳酸脱氢酶(LDH)、D-二聚体比较,差异有统计学意义(P<0.05)。癌症组与非癌症组患者糖类抗原125(CA125)、癌胚抗原(CEA)、糖类抗原724(CA724)、糖类抗原199(CA199)比较,差异有统计学意义(P<0.05)。多因素logistic回归分析,可见Hb、ALB、LDH、D-二聚体、CEA是贫血并癌症的独立危险因素(P<0.05)。结论与贫血非癌症患者相比,贫血并癌症患者的血常规指标、生化指标、肿瘤标记物异常。Hb、ALB、LDH、D-二聚体、CEA是贫血并癌症的独立危险因素。

Objective To explore the hematological changes and risk factors in patients with anemia and cancer.Methods Clinical data of 78 anemia and suspected tumor patients admitted to Third People's Hospital of Shangqiu from January 2022 to December 2023 were retrospectively analyzed,and according to the pathological results of surgery,the patients were divided into cancer group and non-cancer group to compare blood routine markers,biochemical markers,and tumor markers between cancer and non-cancer groups.Multivariate logistic regression model analysis was used to determine the predictive value of each index in cancer.Results Of the 78 patients,24(30.77%)were included in the cancer group and 54(69.23%)were included in the non-cancer group.Among the patients in the cancer group,17(70.83%)had digestive tract tumors.Comparing hemoglobin(Hb),red blood cell distribution width(RDW),neutrophil ratio(NEU),white blood cell count(WBC),neutrophil absolute value(ANC),and platelet distribution width(PDW)between the cancer and non-cancer groups,there was significant difference(P<0.05).Comparing alanine aminotransferase(ALT),albumin(ALB),total protein(TP),lactate dehydrogenase(LDH),D-dimer between cancer group and non-cancer group,there was significant difference(P<0.05).Comparing sugar antigen 125(CA125),carcinoembryonic antigen(CEA),sugar antigen 724(CA724),and sugar antigen 199(CA199)between cancer and non-cancer groups,there was significant difference(P<0.05).In multivariate logistic regression analysis,Hb,ALB,LDH,D-dimer and CEA were independent risk factors for anemia and cancer(P<0.05).Conclusion Blood routine markers,biochemical markers,and tumor markers were abnormal in anemia and cancer patients compared with anemia and non-cancer patients.Hb,ALB,LDH,D-dimer,and CEA are independent risk factors for anemia and cancer.