蛋白降解靶向嵌合体药物的研究进展

Research Progress of Proteolysis Targeting Chimera Drugs

蛋白降解靶向嵌合体(PROTACs)是当前抗肿瘤药物研究的热点之一,具有抗肿瘤作用高效且持久、选择性好、毒性低的特点。文章总结了靶向雌激素受体、雄激素受体、BCR-ABL、组蛋白去乙酰化酶4以及甲基转移酶样3等PROTACs新药的研究进展。

Proteolysis targeting chimeras(PROTACs)are currently one of the hot spots in antineoplastic agent research.They have efficient and durable anti-tumor effects,good selectivity,and low possible toxicity.This review summarizes the research progress of new PROTAC drugs targeting estrogen receptors,androgen receptors,BCR-ABL,histone deacetylase 4,methyltransferase-like 3.